Preparation of tertiary amines via the oxidative coupling of polyfunctional aryl and heteroaryl amidocuprates

被引：29

作者：

Kienle, Marcel ^{[1
]}

Dubbaka, Srinivas Reddy ^{[1
]}

del Amo, Vicente ^{[1
]}

Knochel, Paul ^{[1
]}

机构：

[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany

来源：

SYNTHESIS-STUTTGART | 2007年 / 08期

关键词：

amination; amidocuprates; C-N bond formation; lithium amides; polyfunctional Grignard reagents;

D O I：

10.1055/s-2007-965941

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly functionalized tertiary amines can be prepared by the oxidative coupling of polyfunctional lithium amidocuprates using chloranil as an oxidant. A high functional group tolerance and insensibility to steric hindrance characterize this general amination reaction. Herein, we report a practical procedure for the preparation of aryl and heteroaryl tertiary amines.

引用

页码：1272 / 1278

页数：7

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