The role of LRP8 (ApoER2′) in the pathophysiology of the antiphospholipid syndrome

被引：13

作者：

de Groot, P. G. ^{[1
]}

Derksen, R. H. W. M. ^{[2
]}

Urbanus, R. T. ^{[1
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Clin Chem & Haematol, NL-3584 CX Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dept Rheumatol & Clin Immunol, NL-3584 CX Utrecht, Netherlands

来源：

LUPUS | 2010年 / 19卷 / 04期

关键词：

antiphospholipid serum; GPIb; LDL receptor; ACTIVATED PROTEIN-C; APOLIPOPROTEIN-E RECEPTOR-2'; GLYCOPROTEIN IB-ALPHA; DOMAIN-I; BETA(2)-GLYCOPROTEIN I; LUPUS ANTICOAGULANTS; FACTOR-XI; DIMERIC BETA(2)-GLYCOPROTEIN-I; THROMBIN GENERATION; CRYSTAL-STRUCTURE;

D O I：

10.1177/0961203309360542

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

One of the greatest enigmas in thrombosis research is the observation that one can diagnose a person with a thrombotic risk with a prolongation of the clotting time. Our textbooks have taught us that prolongation of clotting correlates with a tendency to bleed. To confuse our textbook knowledge further, the same patients often have a prolonged bleeding time, a diagnostic test to detect a dysfunction in primary haemostasis. In this paper we critically review the literature that tries to explain the contradiction that exists between in-vitro diagnostic tests and the observed clinical manifestations and discuss our current opinion on how antiphospholipid antibodies can disturb the haemostatic balance. Lupus (2010) 19, 389-393.

引用

页码：389 / 393

页数：5

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