Differential regulation of the oscillations in sympathetic nerve activity and renal blood flow following volume expansion

被引:21
作者
Leonard, BL [1 ]
Navakatikyan, MA [1 ]
Malpas, SC [1 ]
机构
[1] Univ Auckland, Sch Med, Dept Physiol, Circulatory Control Lab, Auckland, New Zealand
来源
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL | 2000年 / 83卷 / 1-2期
关键词
spectral analysis; volume expansion; conscious rabbit;
D O I
10.1016/S0165-1838(00)00103-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Renal sympathetic nerve activity (RSNA) and renal blood flow (RBF) both show oscillations at various frequencies but the functional significance and regulation of these oscillations is not well understood. To establish whether the strength of these oscillations is under differential control we measured the frequency spectrum of RSNA and RBF following volume expansion in conscious rabbits. Seven days prior to experiment animals underwent surgery to implant an electrode for recording renal nerve activity and a flow probe for recording RBF. Volume expansion (Haemaccel, 1.5 ml min(-1) kg(-1) for 15 min) resulted in a 25+/-5% decrease in mean RSNA, paralleled by an increase in RBF to 60+/-12 mi min(-1) from resting levels of 51+/-11 ml min(-1). Renal denervated rabbits did not show an increase in RBF with volume expansion. Arterial baroreflexes were unaltered by volume expansion. Spectral analysis of the different frequencies in RSNA showed oscillations in RSNA between 0.2 and 0.4 Hz were selectively decreased following volume expansion (14+/-3 to 6+/-1% of total power in RSNA at <3 fit). A corresponding decrease in the strength of oscillations in RBF at this frequency was also seen (20 +/- 6 to 8 +/- 2%). In contrast, the strength of respiratory (0.8-2.0 Hz) and cardiac (3-6 Hz) related rhythms did not change with volume expansion. These results show that selective changes in the different frequency components of RSNA can occur. We suggest that input from cardiopulmonary receptors and/or other vascular beds, and/or altered vascular resistance after volume expansion can reduce the strength of the 0.3 Hz oscillation independent of changes in arterial baroreflex control of RSNA. (C) 2000 Published by Elsevier Science B.V.
引用
收藏
页码:19 / 28
页数:10
相关论文
共 31 条
  • [1] Cardiovascular role of parvocellular neurons in the paraventricular nucleus of the hypothalamus
    Badoer, E
    [J]. NEWS IN PHYSIOLOGICAL SCIENCES, 1996, 11 : 43 - 47
  • [2] Cardiac afferents play the dominant role in renal nerve inhibition elicited by volume expansion in the rabbit
    Badoer, E
    Moguilevski, V
    McGrath, BP
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1998, 274 (02) : R383 - R388
  • [3] BERGER RD, 1989, AM J PHYSIOL, V256, P142
  • [4] LOW-FREQUENCY SPONTANEOUS FLUCTUATIONS OF R-R INTERVAL AND BLOOD-PRESSURE IN CONSCIOUS HUMANS - A BARORECEPTOR OR CENTRAL PHENOMENON
    BERNARDI, L
    LEUZZI, S
    RADAELLI, A
    PASSINO, C
    JOHNSTON, JA
    SLEIGHT, P
    [J]. CLINICAL SCIENCE, 1994, 87 (06) : 649 - 654
  • [5] The arterial baroreceptor reflex of the rat exhibits positive feedback properties at the frequency of Mayer waves
    Bertram, D
    Barrès, C
    Cuisinaud, G
    Julien, C
    [J]. JOURNAL OF PHYSIOLOGY-LONDON, 1998, 513 (01): : 251 - 261
  • [6] First-order differential-delay equation for the baroreflex predicts the 0.4-Hz blood pressure rhythm in rats
    Burgess, DE
    Hundley, JC
    Li, SG
    Randall, DC
    Brown, DR
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 273 (06) : R1878 - R1884
  • [7] HEMODYNAMIC FLUCTUATIONS AND BAROREFLEX SENSITIVITY IN HUMANS - A BEAT-TO-BEAT MODEL
    DEBOER, RW
    KAREMAKER, JM
    STRACKEE, J
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1987, 253 (03): : H680 - H689
  • [8] Neural control of renal function
    DiBona, GF
    Kopp, UC
    [J]. PHYSIOLOGICAL REVIEWS, 1997, 77 (01) : 75 - 197
  • [9] THE RENAL SYMPATHETIC BAROREFLEX IN THE RABBIT - ARTERIAL AND CARDIAC BARORECEPTOR INFLUENCES, RESETTING, AND EFFECT OF ANESTHESIA
    DORWARD, PK
    RIEDEL, W
    BURKE, SL
    GIPPS, J
    KORNER, PI
    [J]. CIRCULATION RESEARCH, 1985, 57 (04) : 618 - 633
  • [10] THE CIRCULATORY EFFECTS OF ACUTE HYPERVOLEMIA AND HEMODILUTION IN CONSCIOUS RABBITS
    FARIS, IB
    IANNOS, J
    JAMIESON, GG
    LUDBROOK, J
    [J]. CIRCULATION RESEARCH, 1981, 48 (06) : 825 - 834