Clinical Care of Two Patients with Ebola Virus Disease in the United States

被引：269

作者：

Lyon, G. Marshall ^{[1
]}

Mehta, Aneesh K. ^{[1
]}

Varkey, Jay B. ^{[1
]}

Brantly, Kent ^{[5
]}

Plyler, Lance ^{[5
]}

McElroy, Anita K. ^{[3
,4
]}

Kraft, Colleen S. ^{[1
,2
]}

Towner, Jonathan S. ^{[4
]}

Spiropoulou, Christina ^{[4
]}

Stroeher, Ute ^{[4
]}

Uyeki, Timothy M. ^{[4
]}

Ribner, Bruce S. ^{[1
]}

机构：

[1] Emory Univ, Sch Med, Dept Med, Div Infect Dis, Atlanta, GA USA

[2] Emory Univ, Sch Med, Dept Pathol, Div Infect Dis, Atlanta, GA 30322 USA

[3] Emory Univ, Sch Med, Dept Pediat, Div Infect Dis, Atlanta, GA USA

[4] Ctr Dis Control & Prevent, Atlanta, GA USA

[5] Samaritans Purse, Boone, NC USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2014年 / 371卷 / 25期

关键词：

HEMORRHAGIC-FEVER; INFECTION; FEATURES; KIKWIT; UGANDA; CONGO;

D O I：

10.1056/NEJMoa1409838

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.

引用

页码：2402 / 2409

页数：8

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