The developmental expression dynamics of Drosophila melanogaster transcription factors

被引:18
作者
Adryan, Boris [1 ,2 ,3 ]
Teichmann, Sarah A. [1 ]
机构
[1] MRC, Mol Biol Lab, Struct Studies Div, Computat Biol Grp, Cambridge CB2 2QH, England
[2] Univ Cambridge, Cambridge Syst Biol Ctr, Cambridge CB2 3EH, England
[3] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England
来源
GENOME BIOLOGY | 2010年 / 11卷 / 04期
关键词
GENE REGULATORY NETWORKS; MESODERM DEVELOPMENT; GENOMIC ANALYSIS; PROTEIN; ENCODES; MORPHOGENESIS; EVOLUTION; ENHANCER; REGIONS; SEGMENTATION;
D O I
10.1186/gb-2010-11-4-r40
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: Site-specific transcription factors (TFs) are coordinators of developmental and physiological gene expression programs. Their binding to cis-regulatory modules of target genes mediates the precise cell-and context-specific activation and repression of genes. The expression of TFs should therefore reflect the core expression program of each cell. Results: We studied the expression dynamics of about 750 TFs using the available genomics resources in Drosophila melanogaster. We find that 95% of these TFs are expressed at some point during embryonic development, with a peak roughly between 10 and 12 hours after egg laying, the core stages of organogenesis. We address the differential utilization of DNA-binding domains in different developmental programs systematically in a spatio-temporal context, and show that the zinc finger class of TFs is predominantly early expressed, while Homeobox TFs exhibit later expression in embryogenesis. Conclusions: Previous work, dissecting cis-regulatory modules during Drosophila development, suggests that TFs are deployed in groups acting in a cooperative manner. In contrast, we find that there is rapid exchange of co-expressed partners amongst the fly TFs, at rates similar to the genome-wide dynamics of co-expression clusters. This suggests there may also be a high level of combinatorial complexity of TFs at cis-regulatory modules.
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页数:14
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