Cholestenoic acid is a naturally occurring ligand for liver X receptor α

被引：129

作者：

Song, C ^{[1
]}

Liao, SS ^{[1
]}

机构：

[1] Univ Chicago, Ben May Inst Canc Res, Chicago, IL 60637 USA

来源：

ENDOCRINOLOGY | 2000年 / 141卷 / 11期

关键词：

D O I：

10.1210/en.141.11.4180

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Excessive cholesterol is eliminated from extrahepatic cells by reverse cholesterol transport, a process by which neutral sterols are transferred to extracellular acceptor lipoproteins for further transport to the liver. Another process independent of lipoproteins involves excretion of 3 beta -hydroxy-5-cholesten-25(R)-26-carboxylic (cholestenoic) acid, a metabolite of 27-hydroxycholesterol. Physiological concentrations of cholestenoic acid activated the nuclear receptor liver X receptor alpha (LXR alpha; NR1H3), but not other oxysterol receptors. As a ligand, cholestenoic acid modulated interaction of LXR alpha with the nuclear receptor coactivator Grip-1. Cholestenoic acid, therefore, may function as a signaling molecule for regulation of lipid metabolism via LXR alpha.

引用

页码：4180 / 4184

页数：5

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