Insights into the development of polycystic ovary syndrome (PCOS) from studies of prenatally androgenized female rhesus monkeys

被引：170

作者：

Abbott, DH ^{[1
]}

Dumesic, DA

Eisner, JR

Colman, RJ

Kemnitz, JW

机构：

[1] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Dept Obstet & Gynecol, Madison, WI 53715 USA

[2] Univ Wisconsin, Wisconsin Reg Primate Res Ctr, Dept Endocrinol, Reprod Physiol Training Program, Madison, WI 53715 USA

[3] Mayo Clin, Dept Obstet & Gynecol, Rochester, MN 55905 USA

[4] Univ Wisconsin, Dept Anthropol, Madison, WI 53715 USA

[5] Univ Wisconsin, Dept Med, Madison, WI 53715 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 1998年 / 9卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1043-2760(98)00019-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The developmental pathophysiology of polycystic ovary syndrome (PCOS) is unknown. However, prenatally androgenized female rhesus monkeys exhibit ovarian and endocrinological features that mimic those found in women with PCOS. Thus, prenatal androgen excess may provide an etiology for hyperandrogenism and anovulation in adulthood.

引用

页码：62 / 67

页数：6

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