Chromosomal alterations detected by comparative genomic hybridization in nonfunctioning endocrine pancreatic tumors

被引：15

作者：

Floridia, G

Grilli, G

Salvatore, M

Pescucci, C

Moore, PS

Scarpa, A

Taruscio, D

机构：

[1] Ist Super Sanita, Ctr Nazl Malattie Rare, Dipartimento Biol Cellulare & Neurosci, I-00161 Rome, Italy

[2] Univ Verona, Sect Anat Pathol, Dept Pathol, Verona, Italy

来源：

CANCER GENETICS AND CYTOGENETICS | 2005年 / 156卷 / 01期

关键词：

D O I：

10.1016/j.cancergencyto.2004.04.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have used comparative genomic hybridization to investigate changes in DNA copy number in 20 nonfunctioning endocrine pancreatic tumors. The total number of regional DNA imbalances per tumor showed variation from case to case and high genetic heterogeneity was observed. From 1 to 22 chromosomal anomalies were detected in 13 of the 20 cases evaluated. Overall gains predominated over losses with a ratio of about 3.9:1 (58 gains/15 losses). The mean total number of regions displaying imbalances increased from 1.25 per tumor for benign tumors to 5.25 for malignant tumors, although statistical significance was not reached (P = 0.074). (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：23 / 30

页数：8

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