Bioinspired Self-Healing Hydrogel Based on Benzoxaborole-Catechol Dynamic Covalent Chemistry for 3D Cell Encapsulation

被引：192

作者：

Chen, Yangjun ^{[1
]}

Diaz-Dussan, Diana ^{[1
]}

Wu, Di ^{[2
]}

Wang, Wenda ^{[1
]}

Peng, Yi-Yang ^{[1
]}

Asha, Anika Benozir ^{[1
]}

Hall, Dennis G. ^{[2
]}

Ishihara, Kazuhiko ^{[3
]}

Narain, Ravin ^{[1
]}

机构：

[1] Univ Alberta, Dept Chem & Mat Engn, Edmonton, AB T6G 2G6, Canada

[2] Univ Alberta, Dept Chem, Edmonton, AB T6G 2G6, Canada

[3] Univ Tokyo, Sch Engn, Dept Mat Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan

来源：

ACS MACRO LETTERS | 2018年 / 7卷 / 08期

基金：

加拿大自然科学与工程研究理事会; 加拿大创新基金会;

关键词：

TARGETED DRUG-DELIVERY; MECHANICAL-PROPERTIES; RESPONSIVE HYDROGELS; CONJUGATED OXABOROLE; POLYMER HYDROGEL; PH; NANOPARTICLES; ZWITTERIONS; MEDICINE; GELS;

D O I：

10.1021/acsmacrolett.8b00434

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

Bioinspired Self-Healing Hydrogel Based on Benzoxaborole-Catechol Dynamic Covalent Chemistry for 3D Cell EncapsulationBoronic ester, one typical example of dynamic covalent bonds, has presented great potential to prepare self-healing hydrogels. However, most of currently reported hydrogels based on boronic esters are formed at pH > 8, which impeded their further use in physiological conditions. In this study, we designed two kinds of zwitterionic copolymers with benzoxaborole and catechol pendant groups, respectively. Owing to the lower pKa value of benzoxaborole (7.2), gelation can happen easily at pH 7.4 PBS after mixing these two copolymers due to efficient formation of benzoxaborole-catechol complexations. The resulting hydrogels exhibited excellent self-healing property as well as dual pH/sugar responsiveness due to the dynamic nature of boronic ester. Moreover, benefiting from the cell membrane bioinspired 2-methacryloyloxyethyl phosphorylcholine (MPC)-based polymeric matrix, the hydrogel was further investigated for 3D cell encapsulation. The combination of biocompatible zwitterionic polymers with dynamic benzoxaborole-catechol complexation makes the hydrogels a promising platform for diverse potential bioapplications like drug delivery and tissue engineering.

引用

页码：904 / 908

页数：9

共 54 条

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