HIV vaccines: mosaic approach to virus diversity

被引：22

作者：

Corey, Lawrence ^{[1
,2
,3
]}

McElrath, M. Juliana ^{[1
,3
,4
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Inst, Seattle, WA 98104 USA

[2] Univ Washington, Dept Lab Med, Seattle, WA 98195 USA

[3] Univ Washington, Dept Med, Seattle, WA 98195 USA

[4] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

来源：

NATURE MEDICINE | 2010年 / 16卷 / 03期

关键词：

DOUBLE-BLIND; INFECTION; TRIAL; THAILAND;

D O I：

10.1038/nm0310-268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The extraordinary diversity of HIV is a major barrier in the path of developing a vaccine. One way forward may be mosaic antigens-biometrically designed genes that maximize overlap between sequences used in the vaccine and circulating HIV-1 strains worldwide (pages 319-323 and 324-328).

引用

页码：268 / 270

页数：4

共 11 条

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