Phylogenetic profiles: A graphical method for detecting genetic recombinations in homologous sequences

被引：207

作者：

Weiller, GF ^{[1
]}

机构：

[1] Australian Natl Univ, Res Sch Biol Sci, Bioinformat Lab, Canberra, ACT 0200, Australia

来源：

MOLECULAR BIOLOGY AND EVOLUTION | 1998年 / 15卷 / 03期

关键词：

genetic recombination; computer algorithm; Salmonella enterica; molecular phylogeny; evolution;

D O I：

10.1093/oxfordjournals.molbev.a025929

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phylogenetic profiles constitute a novel way of graphically displaying the coherence of the sequence relationships over the entire length of a set of aligned homologous sequences. Using a sliding-window technique, this method determines the pairwise distances of all sequences in the windows and evaluates, for each sequence, the degree to which the patterns of distances in these regions agree. This method is suited for exploring data consistency as well as detecting recombinant sequences. A computer program implementing the algorithm has been developed, and examples with simulated and natural sequences are given to demonstrate the sensitivity and accuracy of the method for identifying recombinant sequences and their recombination junctions as well as detecting hot spots of recombinational activity.

引用

页码：326 / 335

页数：10

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