AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

被引：1893

作者：

Garcia, Daniel ^{[1
]}

Shaw, Reuben J. ^{[1
]}

机构：

[1] Salk Inst Biol Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

MOLECULAR CELL | 2017年 / 66卷 / 06期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED PROTEIN-KINASE; SKELETAL-MUSCLE; TRANSCRIPTION FACTOR; STRUCTURAL BASIS; UPSTREAM KINASE; DIRECT PHOSPHORYLATION; GLUCOSE-HOMEOSTASIS; MEDIATED REGULATION; UBIQUITIN LIGASE; ADIPOSE-TISSUE;

D O I：

10.1016/j.molcel.2017.05.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

AMPK is a highly conserved master regulator of metabolism, which restores energy balance during metabolic stress both at the cellular and physiological levels. The identification of numerous AMPK targets has helped explain how AMPK restores energy homeostasis. Recent advancements illustrate novel mechanisms of AMPK regulation, including changes in subcellular localization and phosphorylation by non-canonical upstream kinases. Notably, the therapeutic potential of AMPK is widely recognized and heavily pursued for treatment of metabolic diseases such as diabetes, but also obesity, inflammation, and cancer. Moreover, the recently solved crystal structure of AMPK has shed light both into how nucleotides activate AMPK and, importantly, also into the sites bound by small molecule activators, thus providing a path for improved drugs.

引用

页码：789 / 800

页数：12

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