Preparation and evaluation of ibuprofen beads by melt solidification technique

被引：45

作者：

Paradkar, AR ^{[1
]}

Maheshwari, M ^{[1
]}

Ketkar, AR ^{[1
]}

Chauhan, B ^{[1
]}

机构：

[1] Bharati Vidyapeeth Deemed Univ, Dept Pharmaceut, Poona Coll Pharm, Pune 411038, Maharashtra, India

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2003年 / 255卷 / 1-2期

关键词：

ibuprofen DSC; melt solidification; non-disintegrating beads; slow release;

D O I：

10.1016/S0378-5173(03)00081-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel single step melt solidification technique was developed for ibuprofen. DSC studies designed to elucidate the effect of isothermal holding time showed that the extent of crystallization increased with holding time. Agitation speed and polyvinyl alcohol (PVA) were found to reduce the time required for crystallization. The excipient-free. non-disintegrating beads were irregular in shape with high mechanical strength and acceptable flowability. Slow dissolution from beads as attributed to the compactness and higher bond strength of the beads. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：33 / 42

页数：10

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