Melatonin treatment for circadian rhythm sleep disorders

被引：39

作者：

Kamei, Y

Hayakawa, T

Urata, J

Uchiyama, M

Shibui, K

Kim, K

Kudo, Y

Okawa, M

机构：

[1] Natl Ctr Neurol & Psychiat, Kohnodai Hosp, Dept Psychiat, Chiba 2728516, Japan

[2] Natl Ctr Neurol & Psychiat, Natl Inst Mental Hlth, Dept Psychophysiol, Chiba 2728516, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2000年 / 54卷 / 03期

关键词：

delayed sleep phase syndrome; melatonin; non-24 h sleep-wake syndrome; phase shift;

D O I：

10.1046/j.1440-1819.2000.00724.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study investigated the effects of melatonin administration on circadian rhythm sleep disorders, and aimed to clarify clinical characteristics of melatonin responders. The subjects were 46 patients with circadian rhythm sleep disorders: 30 Delayed Sleep Phase Syndrome (DSPS) and 16 non-24 h sleep-wake syndrome (non-24). Patients took 0.3-1.0 mg of melatonin 5, 3 and Ih before habitual bedtime. Seventeen patients responded to melatonin (12 DSPS, five non-24). Comparison of clinical background between responders and non-responders revealed that the responders were characterized by short total sleep time and later onset age of clinical symptoms.

引用

页码：381 / 382

页数：2

共 8 条

[1]

*AM SLEEP DIS ASS, 1990, INT CLASS SLEEP DIS

[2]

COLEMAN RM, 1983, SLEEP WAKE DISORDERS

[3]

CZEISLER CA, 1981, SLEEP, V4, P1

[4] DELAYED SLEEP PHASE SYNDROME RESPONSE TO MELATONIN [J].