Rapid induction of serotonergic hyperinnervation in the adult rat striatum with extensive dopaminergic denervation

被引：68

作者：

Maeda, T

Kannari, K

Shen, H

Arai, A

Tomiyama, M

Matsunaga, M

Suda, T

机构：

[1] Hirosaki Univ, Sch Med, Dept Med 3, Hirosaki, Aomori 0368216, Japan

[2] Hirosaki Univ, Sch Med, Inst Brain Sci, Dept Neurol Sci, Hirosaki, Aomori 0368216, Japan

来源：

NEUROSCIENCE LETTERS | 2003年 / 343卷 / 01期

关键词：

serotonergic hyperinnervation; 6-hydroxydopamine; dopaminergic denervation; immunohistochemistry; serotonin; dopamine; striatum;

D O I：

10.1016/S0304-3940(03)00295-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The aim of our study was to determine whether serotonergic hyperinnervation is rapidly induced in the striatum of adult rats with extensive dopaminergic denervation. Immunohistochemical study was performed on the brain sections obtained at 2 and 8 weeks after injection of 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. The extent of dopaminergic denervation was evaluated as a percentage loss of tyrosine hydroxylase immunopositive neurons in the substantia nigra pars compacta. The immunopositive areas for serotonin (5-HT) in the striatum were measured. In the lesioned rats 97.5 +/- 0.6% of dopamine neurons were lost. 5-HT immunopositive areas in the striatum were significantly increased both at 2 and 8 weeks after 6-OHDA injection (P < 0.01). These results suggest that extensive dopaminergic denervation in adult rats induces rapid serotonergic hyperinnervation in the striatum as early as 2 weeks after lesioning. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：17 / 20

页数：4

共 14 条

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