Pathogenic factors in vascular dementia and Alzheimer's disease - Multiple actions of heparin that probably are beneficial

被引：17

作者：

Engelberg, H ^{[1
]}

机构：

[1] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

来源：

DEMENTIA AND GERIATRIC COGNITIVE DISORDERS | 2004年 / 18卷 / 3-4期

关键词：

vascular dementia; Alzheimer's disease; heparin;

D O I：

10.1159/000080034

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The following areas are discussed in this review: atherogenesis; cerebrovascular factors; hypoperfusion; beta-amyloid production; beta-amyloid fibril formation; beta-sheets; metal cations; reactive oxygen species/free radicals; chronic inflammatory factors; endogenous plasma heparin; lipoprotein lipase; polyamines; protein kinase C; casein kinases; phospholipase A(2); serine proteases; myeloperoxidase; cyclooxygenase 2; cysteine proteases; caspases; proprotein convertases; aspartic proteases; cyclin proteinases; thrombin; tau hyperphosphorylation; advanced glycosylation end products; activator protein 1; calcium; apolipoprotein E epsilon4; histamine; blood-brain barrier; glutamate; transglutaminase; insulin-like growth factor 1. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：278 / 298

页数：21

共 313 条

[1] Chemokines: Leucocyte recruitment and activation cytokines [J].