Expression of T- and L-type calcium channel mRNA in murine sinoatrial node

被引：73

作者：

Bohn, G ^{[1
]}

Moosmang, S ^{[1
]}

Conrad, H ^{[1
]}

Ludwig, A ^{[1
]}

Hofmann, F ^{[1
]}

Klugbauer, N ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Pharmakol & Toxikol, D-80802 Munich, Germany

来源：

FEBS LETTERS | 2000年 / 481卷 / 01期

关键词：

electrophysiology; calcium channel; T-type; L-type; in-situ hybridization; cardiac ion channel;

D O I：

10.1016/S0014-5793(00)01979-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

At the cellular level, cardiac pacemaking which sets the rate and rhythm of the heartbeat is produced by the slow diastolic depolarization. Several ion channels contribute to this pacemaker depolarization, including T-type and L-type calcium currents, To evaluate the molecular basis of the currents involved, me investigated the cellular distribution of various low, voltage activated (LVA) and high voltage activated (HVA) calcium channel mRNAs in the murine sinoatrial (SA) node by in-situ hybridization, The most prominently expressed LVA calcium channel in the SA node is Ca(V)3.1, whereas Ca(V)3.2 is present at moderate levels. The dominant HVA calcium channel transcript is Ca(V)1.2; only traces of Ca(V)1.3 mRNA are detectable in Sri, myocytes of mice, (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：73 / 76

页数：4

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