The effects of the immature rat model of febrile seizures on the occurrence of later generalized tonic-clonic and absence epilepsy

被引：12

作者：

Ates, N ^{[1
]}

Akman, Ö ^{[1
]}

Karson, A ^{[1
]}

机构：

[1] Kocaeli Univ, Fac Med, Dept Physiol, TR-41900 Derince, Kocaeli, Turkey

来源：

DEVELOPMENTAL BRAIN RESEARCH | 2005年 / 154卷 / 01期

关键词：

disorders of the nervous system; epilepsy; basic mechanisms; absence epilepsy; generalized tonic-clonic epilepsy; febrile seizure; pentylenetetrazol; WAG/Rij;

D O I：

10.1016/j.devbrainres.2004.10.001

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

This study was designed to investigate whether the intensity of experimental febrile seizures reduces the threshold to generalized tonic-clonic epilepsy and its effects on the development of generalized absence epilepsy in adulthood. For the evaluation of absence epilepsy, WAG/Rij rats and for the tonic-clonic seizures, PTZ injected Wistar rats were used. Our results showed that while the frequency of the experimental febrile seizures facilitates PTZ-induced generalized tonic-clonic seizures, it does not influence the properties of absence epileptic seizures in adulthood. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：137 / 140

页数：4

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