Asymmetric hydrogenation of α-ethylstyrenes catalyzed by chiral ruthenium complexes

被引：52

作者：

Forman, GS

Ohkuma, T

Hems, WP

Noyori, R ^{[1
]}

机构：

[1] Nagoya Univ, Dept Chem, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Res Ctr Mat Sci, Nagoya, Aichi 4648602, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 49期

基金：

日本学术振兴会;

关键词：

alpha-substituted styrenes; asymmetric hydrogenation; Me-DuPhos-Ru complex;

D O I：

10.1016/S0040-4039(00)01613-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A combined system of RuCl2[(R,R)-Me-DuPhos](dmf)(n) and t-C4H9OK catalyzes the asymmetric hydrogenation of alpha -ethylstyrene derivatives. The reaction proceeds with a substrate to catalyst molar ratio of up to 2600 in 2-propanol at 8 atm and room temperature to give the chiral saturated products in 81-89% ee. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：9471 / 9475

页数：5

共 32 条

[1]

[Anonymous], COMPREHENSIVE ASYMME

[2]

[Anonymous], T METALS ORGANIC SYN

[3] Evidence for a ruthenium dihydride species as the active catalyst in the RuCl2(PPh3)-catalyzed hydrogen transfer reaction in the presence of base [J].