E2A proteins: essential regulators at multiple stages of B-cell development

被引：87

作者：

Kee, BL ^{[1
]}

Quong, MW ^{[1
]}

Murre, C ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

来源：

IMMUNOLOGICAL REVIEWS | 2000年 / 175卷

关键词：

D O I：

10.1034/j.1600-065X.2000.017514.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of mature B lymphocytes from multipotent progenitor cells requires the co-ordinated activities of a number of transcriptional regulatory proteins. The transcription factors encoded by the E2A gene are required for the development of committed B-lineage cells and regulate the expression of essential B-lineage genes at multiple stages of differentiation and activation. in this review we discuss the evidence that the E2A gene products function in the regulation of 1) transcription factors required for B-lineage determination. 2) essential proteins involved in pro-B and pre-B-cell development, 3) accessibilty and recombination of the IgH and IgL chain loci, and 4) isotype switching in activated, mature B lymphocytes.

引用

页码：138 / 149

页数：12

共 97 条

[1] Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice [J].

Akashi, K ;

Kondo, M ;

vonFreedenJeffry, U ;

Murray, R ;

Weissman, IL .

CELL, 1997, 89 (07) :1033-1041

[2] Both E12 and E47 allow commitment to the B cell lineage [J].

Bain, G ;

Maandag, ECR ;

Riele, HPJT ;

Feeney, AJ ;

Sheehy, A ;

Schlissel, M ;

Shinton, SA ;

Hardy, RR ;

Murre, C .

IMMUNITY, 1997, 6 (02) :145-154

[3] Positive and negative regulation of V(D)J recombination by the E2A proteins [J].

Bain, G ;

Romanow, WJ ;

Albers, K ;

Havran, WL ;

Murre, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (02) :289-300

[4] E2A deficiency leads to abnormalities in alpha beta T-cell development and to rapid development of T-cell lymphomas [J].

Bain, G ;

Enel, I ;

Maandag, ECR ;

teRiele, HPJ ;

Voland, JR ;

Sharp, LL ;

Chun, J ;

Huey, B ;

Pinkel, D ;

Murre, C .

MOLECULAR AND CELLULAR BIOLOGY, 1997, 17 (08) :4782-4791

[5] E2A PROTEINS ARE REQUIRED FOR PROPER B-CELL DEVELOPMENT AND INITIATION OF IMMUNOGLOBULIN GENE REARRANGEMENTS [J].

BAIN, G ;

MAANDAG, ECR ;

IZON, DJ ;

AMSEN, D ;

KRUISBEEK, AM ;

WEINTRAUB, BC ;

KROP, I ;

SCHLISSEL, MS ;

FEENEY, AJ ;

VANROON, M ;

VANDERVALK, M ;

TERIELE, HPJ ;

BERNS, A ;

MURRE, C .

CELL, 1994, 79 (05) :885-892

[6] E2A AND E2-2 ARE SUBUNITS OF B-CELL-SPECIFIC E2-BOX DNA-BINDING PROTEINS [J].

BAIN, G ;

GRUENWALD, S ;

MURRE, C .

MOLECULAR AND CELLULAR BIOLOGY, 1993, 13 (06) :3522-3529

[7] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[8] Disruption of αβ but not of γδ T cell development by overexpression of the helix-loop-helix protein Id3 in committed T cell progenitors [J].

Blom, B ;

Heemskerk, MHM ;

Verschuren, MCM ;

van Dongen, JJM ;

Stegmann, APA ;

Bakker, AQ ;

Couwenberg, F ;

Res, PCM ;

Spits, H .

EMBO JOURNAL, 1999, 18 (10) :2793-2802

[9] MUTATIONS OF THE INTRONIC IGH ENHANCER AND ITS FLANKING SEQUENCES DIFFERENTIALLY AFFECT ACCESSIBILITY OF THE J(H)-LOCUS [J].

CHEN, JZ ;

YOUNG, F ;

BOTTARO, A ;

STEWART, V ;

SMITH, RK ;

ALT, FW .

EMBO JOURNAL, 1993, 12 (12) :4635-4645

[10] E47 activates the Ig-heavy chain and TdT loci in non-B cells [J].

Choi, JK ;

Shen, CP ;

Radomska, HS ;

Eckhardt, LA ;

Kadesch, T .

EMBO JOURNAL, 1996, 15 (18) :5014-5021

← 1 2 3 4 5 6 7 8 9 10 →