BDNF and NT-3 modulate expression and threonine phosphorylation of microtubule-associated protein 2 analogues, and alter their distribution in the developing rat cerebral cortex

被引：21

作者：

Fukumitsu, H ^{[1
]}

Ohashi, A ^{[1
]}

Nitta, A ^{[1
]}

Nomoto, H ^{[1
]}

Furukawa, S ^{[1
]}

机构：

[1] Gifu Pharmaceut Univ, Mol Biol Lab, Gifu 502, Japan

来源：

NEUROSCIENCE LETTERS | 1997年 / 238卷 / 03期

关键词：

brain development; brain-derived neurotrophic factor (BDNF); neurotrophin-3 (NT-3); ventricular administration; microtubule-associated protein 2; phosphorylation;

D O I：

10.1016/S0304-3940(97)00852-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Effects of brain-derived neurotrophic factor (BDNF) and neurotrophin (NT)-3 on the expression of structural or synapse-associated proteins were examined in the developing rat cerebral cortex. Following ventricular administration of BDNF or NT-3 at embryonic day (E) 16, expression of microtubule-associated protein (MAP) 2 of 280 kDa was enhanced at E18 and/or E20, and threonine phosphorylation of MAP2 analogues of 120 and 66 kDa was modulated in different ways. NT-3 basically altered the distribution of MAP2 proteins at E20. These findings suggest that NT-3 and BDNF play a role in regulating production and phosphorylation of MAP2 analogues during development of the rat cerebral cortex. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：107 / 110

页数：4

共 20 条

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