Efficacy of micafungin alone or in combination against systemic murine aspergillosis

被引：72

作者：

Luque, JC

Clemons, KV

Stevens, DA

机构：

[1] Santa Clara Valley Med Ctr, Dept Med, Div Infect Dis, San Jose, CA 95128 USA

[2] Univ Rovira & Virgili, E-43201 Reus, Spain

[3] Calif Inst Med Res, San Jose, CA 95128 USA

[4] Stanford Univ, Dept Med, Div Infect Dis & Geog Med, Stanford, CA 94305 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2003年 / 47卷 / 04期

关键词：

D O I：

10.1128/AAC.47.4.1452-1455.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We tested the efficacy of micafungin (FK) alone or in combination with other antifungals against systemic murine aspergillosis. FK alone at 10 mg/kg of body weight/dose prolonged survival (P = 0.01) and reduced CFU in the brain and kidney. Combination therapy that used suboptimal FK with amphotericin B or itraconazole prolonged survival. Although no survivors were free of infection, no antagonism was seen. Nikkomycin Z with FK showed significantly greater potency (P < 0.01) than either alone.

引用

页码：1452 / 1455

页数：4

共 25 条

[1] Synergy, pharmacodynamics, and time-sequenced ultrastructural changes of the interaction between nikkomycin Z and the echinocandin FK463 against Aspergillus fumigatus [J].