Selecting chemicals: the emerging utility of DNA-encoded libraries

被引：66

作者：

Clark, Matthew A. ^{[1
]}

机构：

[1] GlaxoSmithKline Inc, Mol Discovery Res, Waltham, MA 02451 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2010年 / 14卷 / 03期

关键词：

IN-VITRO SELECTION; TEMPLATED SYNTHESIS; SMALL MOLECULES; CHEMISTRY; DESIGN;

D O I：

10.1016/j.cbpa.2010.02.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past 10 years, a handful of academic and industrial research groups have developed strategies for the synthesis and interrogation of DNA-encoded small-molecule libraries. These strategies can be divided into those in which DNA directs small-molecule synthesis and those in which it records the synthesis. These libraries have started to yield novel modulators of biological targets, including: SH3-domain-binding peptoids, macrocyclic peptide-based BcI-X(L)/BH3 interaction disruptors, ligands for TNF, albumin, streptavidin and others, and 'small-molecule kinase inhibitors. The DNA-encoded library field holds the potential to address the general problem of biological ligand discovery, including pharmaceutical lead generation.

引用

页码：396 / 403

页数：8

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