Perianal Paget's disease years after rectal adenocarcinoma removal

BACKGROUNDS. Perianal Paget's disease of then coincides with anorectal carcinoma, which extends into the epidermis from a contiguous organ. OBJECTIVE. Our purpose was to present a patient with perianal Paget's disease who had a rectal adenocarcinoma excised 14 hears previously in another hospital and to determine whether there is a relationship between the perianal Paget's disease and the rectal adenocarcinoma. METHODS. We examined the resected specimens of the rectal adenocarcinoma and the perianal Paget's disease histologically. RESULTS. In the resented specimen of the rectal adenocarcinoma, Paget cells were present within the anal epidermis adjacent to the rectal adenocarcinoma. The Paget cells showed the same histochemical and immunohistological findings as the adenocarcinoma cells. CONCLUSION. There was a close relationship between the perianal Paget's disease and the rectal adenocarcinoma. It is probable that the Paget cells were derived from direct spread from the rectal adenocarcinoma. (C) 1997 by the American Society for Dermatologic Surgery, Inc.