Characteristic signal intensity changes on postmortem magnetic resonance imaging of the brain

被引:54
作者
Kobayashi, Tomoya [1 ]
Shiotani, Seiji [2 ]
Kaga, Kazunori [1 ]
Saito, Hajime [1 ]
Saotome, Kousaku [1 ]
Miyamoto, Katsumi [1 ]
Kohno, Mototsugu [3 ]
Kikuchi, Kazunori [4 ]
Hayakawa, Hideyuki [5 ]
Homma, Kazuhiro
机构
[1] Tsukuba Med Ctr, Dept Radiol Technol, Tsukuba, Ibaraki 3058558, Japan
[2] Tsukuba Med Ctr, Dept Radiol, Tsukuba, Ibaraki 3058558, Japan
[3] Tsukuba Med Ctr, Dept Crit Care & Emergency Med, Tsukuba, Ibaraki 3058558, Japan
[4] Tsukuba Med Ctr, Dept Pathol, Tsukuba, Ibaraki 3058558, Japan
[5] Tsukuba Med Examiners Off, Dept Forens Med, Tsukuba, Ibaraki, Japan
关键词
Postmortem brain CT; Postmortem brain MRI; Postmortem signal intensity change; Global cerebral ischemia; Low body temperature; DELAYED ISCHEMIC HYPERINTENSITY; COMPUTED-TOMOGRAPHY; MRI; AUTOPSY; CAUDOPUTAMEN; FERRITIN; CADAVERS; DENSITY;
D O I
10.1007/s11604-009-0373-9
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Purpose. We investigated and identified postmortem changes on magnetic resonance imaging (MRI) of the brain to provide accurate diagnostic guidelines. Materials and methods. Our subjects were 16 deceased patients (mean age 57 years) who underwent postmortem computed tomography (CT), MRI, and autopsy, the latter of which showed no abnormalities in the brain. The subjects underwent CT and MRI 6-73 h after confirmation of death (mean 26 h), after being kept in cold storage at 4 C. Postmortem MRI of the brain was performed using T1-weighted imaging (T1WI), T2WI, fluid attenuated inversion recovery (FLAIR) imaging, and diffusion weighted imaging (DWI) with parameters identical to those used for living persons. Results. In all cases, postmortem CT showed brain edema and swelling. Postmortem MRI showed characteristic common signal intensity (SI) changes, including (1) high SI of the basal ganglia and thalamus on T1WI; (2) suppression of fat SI on T2WI; (3) insufficient SI suppression of cerebrospinal fluid on FLAIR imaging; (4) high SI rims along the cerebral cortices and the ventricular wall on DWI; and (5) an apparent diffusion coefficient decrease to less than half the normal value. Conclusion. Postmortem MRI of the brain in all cases showed characteristic common SI changes. Global cerebral ischemia without following reperfusion and low body temperature explain these changes.
引用
收藏
页码:8 / 14
页数:7
相关论文
共 45 条
[1]  
Anzai Y, 2004, AM J NEURORADIOL, V25, P274
[2]  
Arbelaez A, 1999, AM J NEURORADIOL, V20, P999
[3]  
BARKOVICH AJ, 2005, PEDIAT NEUROIMAGING, P203
[4]   RELAXATION EFFECTS IN NUCLEAR MAGNETIC RESONANCE ABSORPTION [J].
BLOEMBERGEN, N ;
PURCELL, EM ;
POUND, RV .
PHYSICAL REVIEW, 1948, 73 (07) :679-712
[5]  
Brogdon BG, 1998, FORENSIC RADIOLOGY, Vfirst, P333
[6]   Acute cerebral infarction: Quantification of spin-density and T2 shine-through phenomena on diffusion-weighted MR images [J].
Burdette, JH ;
Elster, AD ;
Ricci, PE .
RADIOLOGY, 1999, 212 (02) :333-339
[7]   Postmortem computed tomography of cadavers embalmed for use in teaching gross anatomy [J].
Chew, Felix S. ;
Relyea-Chew, Annemarie ;
Ochoa, E. Ricardo, Jr. .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 2006, 30 (06) :949-954
[8]  
DAHNERT W, 2006, RADIOLOGY REV MANUAL, P299
[9]   IRON ACCUMULATION IN THE BASAL GANGLIA FOLLOWING SEVERE ISCHEMIC-ANOXIC INSULTS IN CHILDREN [J].
DIETRICH, RB ;
BRADLEY, WG .
RADIOLOGY, 1988, 168 (01) :203-206
[10]   VIRTOPSY: Minimally invasive, imaging-guided virtual autopsy [J].
Dirnhofer, Richard ;
Jackowski, Christian ;
Vock, Peter ;
Potter, Kimberlee ;
Thali, Michael J. .
RADIOGRAPHICS, 2006, 26 (05) :1305-1333