Disappearance of intramolecular stacking due to one-atom movement or increment of a 'propylene linker' in pyrazolo[3,4-d]pyrimidine-based flexible models

被引：21

作者：

Maulik, PR ^{[1
]}

Avasthi, K

Sarkhel, S

Chandra, T

Rawat, DS

Logsdon, B

Jacobson, RA

机构：

[1] Cent Drug Res Inst, Div Membrane Biol, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

[3] Iowa State Univ, Dept Chem, Ames, IA 50011 USA

来源：

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS | 2000年 / 56卷 / 11期

关键词：

Alkylation - Evaporation - Stacking faults - Synthesis (chemical) - X ray crystallography;

D O I：

10.1107/S0108270100010775

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the crystal structures of 4,6-dimethylthio-1-[3-(4,6-dimethylthio-2H-pyrazolo[3,4-d]pyrimidin-2-yl)propyl]-1H-pyrazolo[3,4-d]pyrimidine, C17H20N8S4, and 1-[4-(4-methoxy-6-methylthio-1H-pyrazolo[3,4-d]pyrimidin-1-yl)butyl]-5-methyl-6-methylthio-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one, C18H22N8O2S2, only intermolecular stacking due to aromatic pi-pi interactions between pyrazolo[3,4-d]pyrimidine rings is present.

引用

页码：1361 / 1363

页数：3

共 14 条

[1]

AVASTHI K, 1995, INDIAN J CHEM B, V34, P944

[2]

Avasthi K, 1998, INDIAN J CHEM B, V37, P1228

[3]

Avasthi K, 1998, INDIAN J CHEM B, V37, P754

[4] 1,3-BIS[4,6-BIS(METHYLTHIO)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-1-YL]PROPANE [J].

BISWAS, G ;

CHANDRA, T ;

AVASTHI, K ;

MAULIK, PR .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1995, 51 :2453-2455

[5]

BROWN DT, 1968, J AM CHEM SOC, V90, P7300

[6] NRCVAX - AN INTERACTIVE PROGRAM SYSTEM FOR STRUCTURE-ANALYSIS [J].

GABE, EJ ;

LEPAGE, Y ;

CHARLAND, JP ;

LEE, FL ;

WHITE, PS .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1989, 22 :384-387

[7] Structure, energetics, and dynamics of the nucleic acid base pairs:: Nonempirical ab initio calculations [J].

Hobza, P ;

Sponer, J .

CHEMICAL REVIEWS, 1999, 99 (11) :3247-3276

[8]

Johnson C.K., 1965, ORTEP Report ORNL-3794

[9]

KARCHER B, 1981, THESIS IOWA STATE U, P64

[10] A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule [J].

Maulik, PR ;

Avasthi, K ;

Biswas, G ;

Biswas, S ;

Rawat, DS ;

Sarkhel, S ;

Chandra, T ;

Bhakuni, DS .

ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1998, 54 :275-277

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