An outbreak of asthma in a modern detergent factory

被引：103

作者：

Cullinan, P ^{[1
]}

Harris, JM ^{[1
]}

Taylor, AJN ^{[1
]}

Hole, AM ^{[1
]}

Jones, M ^{[1
]}

Barnes, F ^{[1
]}

Jolliffe, G ^{[1
]}

机构：

[1] Imperial Coll Sch Med, Dept Occupat & Environm Med, London SW3 6LR, England

来源：

LANCET | 2000年 / 356卷 / 9245期

关键词：

D O I：

10.1016/S0140-6736(00)03264-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The striking decrease in the occurrence of protease-induced occupational asthma in the detergent industry has been attributed to enzyme encapsulation. We report an outbreak of asthma, at least equal in sire to those reported in the 1960s, in a modern European factory which has exclusively used encapsulated enzymes. A survey revealed that enzyme sensitisation and work-related respiratory symptoms were positively correlated with airborne enzyme exposure. We suggest that encapsulation alone is insufficient to prevent enzyme-induced allergy and asthma.

引用

页码：1899 / 1900

页数：2

共 5 条

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[2]

FLINDT MLH, 1969, LANCET, V1, P1177

[3]

JUNIPER CP, 1977, J SOC OCCUP MED, V27, P3

[4]

PERDU D, 1992, REV MAL RESPIR, V9, P443

[5] Proteolytic detergent enzymes enhance the allergic antibody responses of guinea pigs to nonproteolytic detergent enzymes in a mixture: Implications for occupational exposure [J].

Sarlo, K ;

Ritz, HL ;

Fletcher, ER ;

Schrotel, KR ;

Clark, ED .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1997, 100 (04) :480-487

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