Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

被引：208

作者：

Lahortiga, Idoya

De Keersmaecker, Kim

Van Vlierberghe, Pieter

Graux, Carlos

Cauwelier, Barbara

Lambert, Frederic

Mentens, Nicole

Beverloo, H. Berna

Pieters, Rob

Speleman, Frank

Odero, Maria D.

Bauters, Marijke

Froyen, Guy

Marynen, Peter

Vandenberghe, Peter

Wlodarska, Iwona

Meijerink, Jules P. P.

Cools, Jan ^{[1
]}

机构：

[1] VIV, Dept Mol & Dev Genet, Human Genome Lab, Louvain, Belgium

[2] Katholieke Univ Leuven, Ctr Human Genet, Human Genome Lab, Louvain, Belgium

[3] Univ Navarra, Div Oncol, Ctr Appl Med Res, E-31080 Pamplona, Spain

[4] Sophia Childrens Univ Hosp, Erasmus Med Ctr, Dept Pediat Oncol Hematol, Rotterdam, Netherlands

[5] Catholic Univ Louvain, Clin Univ, Dept Hematol, Yvoir, Belgium

[6] Ghent Univ Hosp, Ctr Genet Med, B-9000 Ghent, Belgium

[7] Univ Liege, Dept Human Genet, Ctr Biomed Integrated Genoproteom, Liege, Belgium

[8] Erasmus MC, Dept Clin Genet, Rotterdam, Netherlands

来源：

NATURE GENETICS | 2007年 / 39卷 / 05期

关键词：

D O I：

10.1038/ng2025

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

引用

页码：593 / 595

页数：3

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