Genetic screening for signal transduction in the era of network biology

被引：126

作者：

Friedman, Adam ^{[1
]}

Perrimon, Norbert ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Genet, Boston, MA 02175 USA

来源：

CELL | 2007年 / 128卷 / 02期

关键词：

D O I：

10.1016/j.cell.2007.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating time-dependent quantitative contributions, and suggest how this new framework can impact our study of human disease.

引用

页码：225 / 231

页数：7

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