Finding footprints among the trees

被引:12
作者
Klenerman, Paul
McMichael, Andrew
机构
[1] Univ Oxford, Nuffield Dept Clin Med, Oxford OX1 3SY, England
[2] Univ Oxford, John Radcliffe Hosp, Inst Mol Med, Oxford OX3 9DS, England
基金
英国医学研究理事会;
关键词
D O I
10.1126/science.1140768
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
High-quality statistical analyses allow tracking of HIV evasion of the host immune response through epitope mutations and suggest refined strategies for vaccine development.
引用
收藏
页码:1505 / 1507
页数:3
相关论文
共 18 条
[1]   Founder effects in the assessment of HIV polymorphisms and HLA allele associations [J].
Bhattacharya, Tanmoy ;
Daniels, Marcus ;
Heckerman, David ;
Foley, Brian ;
Frahm, Nicole ;
Kadie, Carl ;
Carlson, Jonathan ;
Yusim, Karina ;
McMahon, Ben ;
Gaschen, Brian ;
Mallal, Simon ;
Mullins, James I. ;
Nickle, David C. ;
Herbeck, Joshua ;
Rousseau, Christine ;
Learn, Gerald H. ;
Miura, Toshiyuki ;
Brander, Christian ;
Walker, Bruce ;
Korber, Bette .
SCIENCE, 2007, 315 (5818) :1583-1586
[2]   Antiviral pressure exerted by HIV-1-specific cytotoxic T lymphocytes (CTLs) during primary infection demonstrated by rapid selection of CTL escape virus [J].
Borrow, P ;
Lewicki, H ;
Wei, XP ;
Horwitz, MS ;
Peffer, N ;
Meyers, H ;
Nelson, JA ;
Gairin, JE ;
Hahn, BH ;
Oldstone, MBA ;
Shaw, GM .
NATURE MEDICINE, 1997, 3 (02) :205-211
[3]   Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef [J].
Evans, DT ;
O'Connor, DH ;
Jing, PC ;
Dzuris, JL ;
Sidney, J ;
da Silva, J ;
Allen, TM ;
Horton, H ;
Venham, JE ;
Rudersdorf, RA ;
Vogel, T ;
Pauza, CD ;
Bontrop, RE ;
DeMars, R ;
Sette, A ;
Hughes, AL ;
Watkins, DI .
NATURE MEDICINE, 1999, 5 (11) :1270-1276
[4]   Polyvalent vaccines for optimal coverage of potential T-cell epitopes in global HIV-1 variants [J].
Fischer, Will ;
Perkins, Simon ;
Theiler, James ;
Bhattacharya, Tanmoy ;
Yusim, Karina ;
Funkhouser, Robert ;
Kuiken, Carla ;
Haynes, Barton ;
Letvin, Norman L. ;
Walker, Bruce D. ;
Hahn, Beatrice H. ;
Korber, Bette T. .
NATURE MEDICINE, 2007, 13 (01) :100-106
[5]   Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection [J].
Gaudieri, Silvana ;
Rauch, Andri ;
Park, Lawrence P. ;
Freitas, Elizabeth ;
Herrmann, Susan ;
Jeffrey, Gary ;
Cheng, Wendy ;
Pfafferott, Katja ;
Naidoo, Kiloshni ;
Chapman, Russell ;
Battegay, Manuel ;
Weber, Rainer ;
Telenti, Amalio ;
Furrer, Hansjakob ;
James, Ian ;
Lucas, Michaela ;
Mallal, Simon A. .
JOURNAL OF VIROLOGY, 2006, 80 (22) :11094-11104
[6]   Late escape from an immunodominant cytotoxic T-lymphocyte response associated with progression to AIDS [J].
Goulder, PJR ;
Phillips, RE ;
Colbert, RA ;
McAdam, S ;
Ogg, G ;
Nowak, MA ;
Giangrande, P ;
Luzzi, G ;
Morgan, B ;
Edwards, A ;
McMichael, AJ ;
RowlandJones, S .
NATURE MEDICINE, 1997, 3 (02) :212-217
[7]   Conflicting selective forces affect T cell receptor contacts in an immunodominant human immunodeficiency virus epitope [J].
Iversen, AKN ;
Stewart-Jones, G ;
Learn, GH ;
Christie, N ;
Sylvester-Hviid, C ;
Armitage, AE ;
Kaul, R ;
Beattie, T ;
Lee, JK ;
Li, YP ;
Chotiyarnwong, P ;
Dong, T ;
Xu, XN ;
Luscher, MA ;
MacDonald, K ;
Ullum, H ;
Klarlund-Pedersen, B ;
Skinhoj, P ;
Fugger, L ;
Buus, S ;
Mullins, JI ;
Jones, EY ;
van der Merwe, PA ;
McMichael, AJ .
NATURE IMMUNOLOGY, 2006, 7 (02) :179-189
[8]   Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response [J].
Jones, NA ;
Wei, XP ;
Flower, DR ;
Wong, ML ;
Michor, F ;
Saag, MS ;
Hahn, BH ;
Nowak, MA ;
Shaw, GM ;
Borrow, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (10) :1243-1256
[9]   Clustered mutations in HIV-1 gag are consistently required for escape from HLA-B27-restricted cytotoxic T lymphocyte responses [J].
Kelleher, AD ;
Long, C ;
Holmes, EC ;
Allen, RL ;
Wilson, J ;
Conlon, C ;
Workman, C ;
Shaunak, S ;
Olson, K ;
Goulder, P ;
Brander, C ;
Ogg, G ;
Sullivan, JS ;
Dyer, W ;
Jones, I ;
McMichael, AJ ;
Rowland-Jones, S ;
Phillips, RE .
JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 193 (03) :375-385
[10]   Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA [J].
Leslie, A ;
Kavanagh, D ;
Honeyborne, I ;
Pfafferott, K ;
Edwards, C ;
Pillay, T ;
Hilton, L ;
Thobakgale, C ;
Ramduth, D ;
Draenert, R ;
Le Gall, S ;
Luzzi, G ;
Edwards, A ;
Brander, C ;
Sewell, AK ;
Moore, S ;
Mullins, J ;
Moore, C ;
Mallal, S ;
Bhardwaj, N ;
Yusim, K ;
Phillips, R ;
Klenerman, P ;
Korber, B ;
Kiepiela, P ;
Walker, B ;
Goulder, P .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (06) :891-902