Mechanisms of regulation of transcription factor HIF under hypoxia

被引：10

作者：

Anokhina, E. B. ^{[1
]}

Buravkova, L. B. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Biomed Problems, Moscow 123007, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2010年 / 75卷 / 02期

关键词：

hypoxia; transcription factor HIF; ACTIVATED PROTEIN-KINASES; MITOCHONDRIAL RESPIRATORY-CHAIN; CULTURED MESANGIAL CELLS; GENE-EXPRESSION; INDUCIBLE FACTOR; ENDOTHELIAL-CELLS; CARDIAC MYOCYTES; C-JUN; OXYGEN; HIF-1-ALPHA;

D O I：

10.1134/S0006297910020057

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The importance of transcription factor HIF in cellular response to hypoxia and various regulatory levels determining its functioning within cells are considered. Special attention is paid to important links of the hypoxia-triggered HIFmediated mechanism. The review contains retrospective analysis of the search for cellular primary oxygen sensors and their interactions with HIF. It also deals with the interrelation of HIF-mediated and other hypoxia-activated mechanisms and outlines importance of HIF subunits in the cell.

引用

页码：151 / 158

页数：8

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