The pathogenetic role of HLA-B27 in chronic arthritis

被引：66

作者：

de Castro, JAL ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(98)80033-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Population and peptide specificity analyses and studies in transgenic rodents support a role of HLA-B27 as an antigen-presenting molecule in spondyloarthropathy. The interplay between HLA-B27 and arthritogenic bacteria on infected cells suggests that HLA-B27 might also influence disease by other mechanisms. Recent genetic advances promise the identification of additional susceptibility genes.

引用

页码：59 / 66

页数：8

共 75 条

[1] Weak association between HLA-B27 and the spondylarthropathies in Lebanon [J].

Awada, H ;

Baddoura, R ;

Naman, R ;

Klayme, S ;

Mansour, I ;

Tamouza, R ;

Marzais, F ;

Raffoux, C ;

Toubert, A ;

Charron, D .

ARTHRITIS AND RHEUMATISM, 1997, 40 (02) :388-389

[2] T-cell receptor usage in alloreactivity against HLA-B*2703 reveals significant conservation of the antigenic structure of B*2705 [J].

Barber, DF ;

Obeso, D ;

GarciaHoyo, R ;

Villadangos, JA ;

deCastro, JAL .

TISSUE ANTIGENS, 1996, 47 (06) :478-484

[3] GUILT BY ASSOCIATION - HLA-B27 AND ANKYLOSING-SPONDYLITIS [J].

BENJAMIN, R ;

PARHAM, P .

IMMUNOLOGY TODAY, 1990, 11 (04) :137-142

[4] Differences in endogenous peptides presented by HLA-B*2705 and B*2703 allelic variants - Implications for susceptibility to spondylarthropathies [J].

Boisgerault, F ;

Tieng, V ;

Stolzenberg, MC ;

Dulphy, N ;

Khalil, I ;

Tamouza, R ;

Charron, D ;

Toubert, A .

JOURNAL OF CLINICAL INVESTIGATION, 1996, 98 (12) :2764-2770

[5] TRANSFER OF THE INFLAMMATORY DISEASE OF HLA-B27 TRANSGENIC RATS BY BONE-MARROW ENGRAFTMENT [J].

BREBAN, M ;

HAMMER, RE ;

RICHARDSON, JA ;

TAUROG, JD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (05) :1607-1616

[6]

Breban M, 1996, J IMMUNOL, V156, P794

[7] Ankylosing spondylitis in west Africans - Evidence for a non-HLA-B27 protective effect [J].

Brown, MA ;

Jepson, A ;

Young, A ;

Whittle, HC ;

Greenwood, BM ;

Wordsworth, BP .

ANNALS OF THE RHEUMATIC DISEASES, 1997, 56 (01) :68-70

[8] Susceptibility to ankylosing spondylitis in twins - The role of genes, HLA, and the environment [J].

Brown, MA ;

Kennedy, LG ;

MacGregor, AJ ;

Darke, C ;

Duncan, E ;

Shatford, JL ;

Taylor, A ;

Calin, A ;

Wordsworth, P .

ARTHRITIS AND RHEUMATISM, 1997, 40 (10) :1823-1828

[9]

Brown Matthew, 1997, Current Opinion in Rheumatology, V9, P308

[10] IMMUNOMODULATION BY SOLUBLE HLA CLASS-I [J].

BUELOW, R ;

BURLINGHAM, WJ ;

CLAYBERGER, C .

TRANSPLANTATION, 1995, 59 (05) :649-654

← 1 2 3 4 5 6 7 8 →