Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT4 in skeletal muscle

被引：105

作者：

Leturque, A ^{[1
]}

Loizeau, M ^{[1
]}

Vaulont, S ^{[1
]}

Salminen, M ^{[1
]}

Girard, J ^{[1
]}

机构：

[1] INSERM,U129,INST COCHIN GENET MOLEC,F-75014 PARIS,FRANCE

来源：

DIABETES | 1996年 / 45卷 / 01期

关键词：

D O I：

10.2337/diabetes.45.1.23

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To investigate the role of glucose transporter expression in whole-body glucose homeostasis, we have created transgenic mice that have a 2.0- to 3.5-fold increase in GLUT4 glucose transporter level in skeletal muscle and heart, This increase is sufficient to significantly improve insulin action and to reduce basal blood glucose levels in transgenic streptozotocin-induced diabetic mice. These results provide the first evidence of a direct causality between skeletal muscle GLUT4 transporter level and overall insulin responsiveness.

引用

页码：23 / 27

页数：5

共 29 条

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