Synthesis and stabilities of the Ga(III) and In(III) chelates of a new diaminodithiol bifunctional ligand

被引：11

作者：

Sun, YZ

Martell, AE ^{[1
]}

Motekaitis, RJ

Welch, MJ

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA

[2] Washington Univ, Sch Med, Edward Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

来源：

TETRAHEDRON | 1998年 / 54卷 / 17期

基金：

美国国家科学基金会;

关键词：

gallium(III) complexes; indium(III) complexes; bifunctional ligand; diaminodithiol;

D O I：

10.1016/S0040-4020(98)00121-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a new bifunctional ligand 1-(4-carboxymethoxybenzyl)-N,N'-bis[(2-mercapto-2,2-dimethyl)ethyl]-1,2-ethylenediamine-N,N'-diacetic acid (B6SS) is described. It consists of substitution of a side-chain, a 4-carboxymethoxybenzyl group on a carbon atom of the ethylenediamine moiety of a hexadentate ligand, 6SS, which has been found to have a very high affinity for in(ni). Potentiometric determination of Ga(III) and In(III) chelate stabilities of the bifunctional ligand show that the side-chain on the ligand reduces the pM values about 2-4 log values. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：4203 / 4210

页数：8

共 11 条

[1] N,N'-ETHYLENE-DI-L-CYSTEINE (EC) COMPLEXES OF GA(III) AND IN(III) - MOLECULAR MODELING, THERMODYNAMIC STABILITY AND IN-VIVO STUDIES [J].