Lymphoid lineage cells in adult murine bone marrow diverge from those of other blood cells at an early, hormone-sensitive stage

被引：18

作者：

Kincade, PW

Igarashi, H

Medina, KL

Kouro, T

Yokota, T

Rossi, MID

Owen, JJT

Garrett, KP

Sun, XH

Sakaguchi, N

机构：

[1] Oklahoma Med Res Fdn, Immunobiol & Canc Program, Oklahoma City, OK 73104 USA

[2] Kumamoto Univ, Sch Med, Dept Immunol, Kumamoto 860, Japan

来源：

SEMINARS IN IMMUNOLOGY | 2002年 / 14卷 / 06期

关键词：

B lymphocytes; NK cells; stem cells; steroid hormones; T lymphocytes;

D O I：

10.1016/S1044532302000738

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Advances in cell sorting and GFP knock-in technology have made it possible to identify rare hematopoietic cells in marine bone marrow that are undergoing lymphocyte fate specification. Steroid hormones also represent important research tools for investigating relationships between different categories of lympho-hematopoietic precursors. By selectively blocking entry into and progression within lymphoid lineages, the hormones probably have a major influence on numbers of lymphocytes that are produced under normal circumstances. These issues are discussed within the context of developmental age-dependent changes that occur in the lymphopoietic process.

引用

页码：385 / 394

页数：10

共 64 条

[1] Upregulation of flt3 expression within the bone marrow Lin-Sca1+c-kit+ stem cell compartment is accompanied by loss of self-renewal capacity [J].