A human monoclonal antibody cocktail as a novel component of rabies postexposure prophylaxis

被引：54

作者：

de Kruif, John ^{[1
]}

Bakker, Alexander B. H.

Marissen, Wilfred E.

Kramer, R. Arjen

Throsby, Mark

Rupprecht, Charles E.

Goudsmit, Jaap

机构：

[1] Crucell Holland BV, Leiden, Netherlands

[2] Ctr Dis Control & Prevent, Rabies Sect, Div Viral & Rickettsial Dis, Atlanta, GA 30333 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2007年 / 58卷

关键词：

polyclonal; serum; phage display; IgG;

D O I：

10.1146/annurev.med.58.061705.145053

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The currently recommended treatment for individuals exposed to rabies virus is the combined administration of rabies vaccine and rabies immune globulin (RIG). This review sets out the criteria used to guide development of a cocktail of human monoclonal antibodies as a replacement for RIG. Using this process as a model, the general requirements for development of safe and efficacious monoclonal antibody alternatives to currently used polyclonal serum products are discussed.

引用

页码：359 / 368

页数：12

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