Genetic basis of antibiotic resistance in Streptococcus agalactiae strains isolated in a French hospital

被引:90
作者
Poyart, C
Jardy, L
Quesne, G
Berche, P
Trieu-Cuot, P
机构
[1] Fac Med Necker Enfants Malad, Lab Mixte Pasteur Necker Rech Streptocoques & Str, F-75730 Paris 15, France
[2] Hop Necker Enfants Malad, Microbiol Lab, F-75015 Paris, France
[3] Fac Med Necker Enfants Malad, INSERM U570, F-75015 Paris, France
关键词
D O I
10.1128/AAC.47.2.794-797.2003
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The genetic basis of antibiotic resistance in 113 unrelated group B streptococci was studied by PCR. Ninety-four strains were resistant to tetracycline-minocycline, and tet(M) was detected in 85% of these isolates. Seventeen erythromycin-resistant strains contained the erm(B), erm(TR), or mef(A) gene. Eleven strains exhibited high-level resistance to kanamycin due to the presence of the aphA3 gene; eight of these strains were also highly resistant to streptomycin; aad-6-related sequences were detected in seven strains.
引用
收藏
页码:794 / 797
页数:4
相关论文
共 25 条
[1]   Group B streptococci causing neonatal bloodstream infection: Antimicrobial susceptibility and serotyping results from SENTRY centers in the Western Hemisphere [J].
Andrews, JI ;
Diekema, DJ ;
Hunter, SK ;
Rhomberg, PR ;
Pfaller, MA ;
Jones, RN ;
Doern, GV .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 2000, 183 (04) :859-862
[2]   Resistance to macrolides in Streptococcus pyogenes in France in pediatric patients [J].
Bingen, E ;
Fitoussi, F ;
Doit, C ;
Cohen, R ;
Tanna, A ;
George, R ;
Loukil, C ;
Brahimi, N ;
Le Thomas, I ;
Deforche, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (06) :1453-1457
[3]   Invasive group B streptococcal disease: The emergence of serotype V [J].
Blumberg, HM ;
Stephens, DS ;
Modansky, M ;
Erwin, M ;
Elliot, J ;
Facklam, RR ;
Schuchat, A ;
Baughman, W ;
Farley, MM .
JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (02) :365-373
[4]   Cloning and characterization of a novel macrolide efflux gene, mreA, from Streptococcus agalactiae [J].
Clancy, J ;
DibHajj, F ;
Petitpas, JW ;
Yuan, W .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (12) :2719-2723
[5]   Molecular cloning and functional analysis of a novel macrolide-resistance determinant, mefA, from Streptococcus pyogenes [J].
Clancy, J ;
Petitpas, J ;
DibHajj, F ;
Yuan, W ;
Cronan, M ;
Kamath, AV ;
Bergeron, J ;
Retsema, JA .
MOLECULAR MICROBIOLOGY, 1996, 22 (05) :867-879
[6]   New tetracycline resistance determinants coding for ribosomal protection in streptococci and nucleotide sequence of tet(T) isolated from Streptococcus pyogenes A498 [J].
Clermont, D ;
Chesneau, O ;
deCespedes, G ;
Horaud, T .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (01) :112-116
[7]  
*COM ANT SOC FRANC, 1999, COMM 1999 SOC FRANC
[8]   Prevalence and mechanisms of macrolide resistance in invasive and noninvasive group B streptococcus isolates from Ontario, Canada [J].
de Azavedo, JCS ;
McGavin, M ;
Duncan, C ;
Low, DE ;
McGeer, A .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (12) :3504-3508
[9]   Antibiotic susceptibility and mechanisms of erythromycin resistance in clinical isolates of Streptococcus agalactiae:: French multicenter study [J].
De Mouy, D ;
Cavallo, JD ;
Leclercq, R ;
Fabre, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (08) :2400-2402
[10]   Sudden increase in isolation of group B streptococci, serotype V, is not due to emergence of a new pulsed-field gel electrophoresis type [J].
Elliott, JA ;
Farmer, KD ;
Facklam, RR .
JOURNAL OF CLINICAL MICROBIOLOGY, 1998, 36 (07) :2115-2116