Matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases 1 in influenza-associated encephalopathy

被引：52

作者：

Ichiyama, Takashi

Morishima, Tsuneo

Kajimoto, Madoka

Matsushige, Takeshi

Matsubara, Tomoyo

Furukawa, Susumu

机构：

[1] Yamaguchi Univ, Sch Med, Dept Pediat, Ube, Yamaguchi 7558505, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Pediat, Okayama 7008530, Japan

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2007年 / 26卷 / 06期

关键词：

Epstein-Barr virus; influenza-associated encephalopathy; MMP-9; respiratory syncytial virus; TIMP-1;

D O I：

10.1097/INF.0b013e31803994a0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Matrix metalloproteinase-9 (MMP-9) and tissue inhibitors of metalloprotemases 1 (TIMP-1) play important roles in the function of the blood-brain barrier. Serum MMP-9 and TIMP-1 concentrations were determined in influenza virus infection with or without neurologic complications. Our results suggest that an imbalance between MMP-9 and TIMP-1 damages the blood-brain barrier and promotes febrile seizure or encephalopathy in influenza virus infection.

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收藏

页码：542 / 544

页数：3

相关论文

共 10 条

[1] Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: An overview [J].

Chandler, S ;

Miller, KM ;

Clements, JM ;

Lury, J ;

Corkill, D ;

Anthony, DCC ;

Adams, SE ;

Gearing, AJH .

JOURNAL OF NEUROIMMUNOLOGY, 1997, 72 (02) :155-161

[2] Tumor necrosis factor-α, interleukin-1β, and interleukin-6 in cerebrospinal fluid from children with prolonged febrile seizures -: Comparison with acute encephalitis/encephalopathy [J].

Ichiyama, T ;

Nishikawa, M ;

Yoshitomi, T ;

Hayashi, T ;

Furukawa, S .

NEUROLOGY, 1998, 50 (02) :407-411

[3] Analysis of cytokine levels and NF-κB activation in peripheral blood mononuclear cells in influenza virus-associated encephalopathy [J].

Ichiyama, T ;

Morishima, T ;

Isumi, H ;

Matsufuji, H ;

Matsubara, T ;

Furukawa, S .

CYTOKINE, 2004, 27 (01) :31-37

[4] Cerebrospinal fluid and serum levels of cytokines and soluble tumor necrosis factor receptor in influenza virus-associated encephalopathy [J].

Ichiyama, T ;

Isumi, H ;

Ozawa, H ;

Matsubara, T ;

Morishima, T ;

Furukawa, S .

SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES, 2003, 35 (01) :59-61

[5] Serum cytokine concentrations of influenza-associated acute necrotizing encephalopathy [J].

Ichiyama, T ;

Endo, S ;

Kaneko, M ;

Isumi, H ;

Matsubara, T ;

Furukawa, S .

PEDIATRICS INTERNATIONAL, 2003, 45 (06) :734-736

[6] IL-10 INHIBITS METALLOPROTEINASE AND STIMULATES TIMP-1 PRODUCTION IN HUMAN MONONUCLEAR PHAGOCYTES [J].

LACRAZ, S ;

NICOD, LP ;

CHICHEPORTICHE, R ;

WELGUS, HG ;

DAYER, JM .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 96 (05) :2304-2310

[7] Extracellular matrix degradation by metalloproteinases and central nervous system diseases [J].

Lukes, A ;

Mun-Bryce, S ;

Lukes, M ;

Rosenberg, GA .

MOLECULAR NEUROBIOLOGY, 1999, 19 (03) :267-284

[8] Encephalitis and encephalopathy associated with an influenza epidemic in Japan [J].

Morishima, T ;

Togashi, T ;

Yokota, S ;

Okuno, Y ;

Miyazaki, C ;

Tashiro, M ;

Okabe, N .

CLINICAL INFECTIOUS DISEASES, 2002, 35 (05) :512-517

[9] Influenza-associated acute encephalopathy in Japanese children in 1994-2002 [J].

Togashi, T ;

Matsuzono, Y ;

Narita, M ;

Morishima, T .

VIRUS RESEARCH, 2004, 103 (1-2) :75-78

[10] Influenza A virus infection modulates the expression of type IV collagenase in epithelial cells [J].

Yeo, SJ ;

Kim, SJ ;

Kim, JH ;

Lee, HJ ;

Kook, YH .

ARCHIVES OF VIROLOGY, 1999, 144 (07) :1361-1370