Failure to acquire new semantic knowledge in patients with large medial temporal lobe lesions

被引:55
作者
Bayley, PJ
Squire, LR
机构
[1] Vet Affairs Med Ctr, San Diego, CA 92161 USA
[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Psychol, La Jolla, CA 92093 USA
关键词
memory; semantic learning; amnesia;
D O I
10.1002/hipo.20057
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
We examined new semantic learning in two profoundly amnesic patients (E.P. and G.P.) whose lesions involve virtually the entire medial temporal lobe (MTL) bilaterally. The patients were given five tests of semantic knowledge for information that could only have been acquired after the onset of their amnesia in 1992 and 1987, respectively. Age-matched and education-matched controls (n = 8) were also tested. On tests of recall, E.P. and G.P. each scored 10% correct on a test of 20 easy factual questions (controls = 90%), 2% and 4% correct on 55 questions about news events (controls = 85%), and 0% and 4% correct on a test of 24 famous faces. On three tests of recognition memory for this same material, the patients scored at chance levels. Similarly, the patients were unable to judge whether persons who had been famous for many decades were still living or had died during the past 10 years (E.P. = 53%; G.P. = 50%; controls = 73%; chance = 50%). Lastly, neither patient E.P. nor patient G.P. could draw an accurate floor plan of his current residence, despite having lived there for 10 years and 1 year, respectively. The results demonstrate that the capacity for new semantic learning can be absent, or nearly absent, when there is virtually complete damage to the MTL bilaterally. Accordingly, the results raise the possibility that the acquisition of conscious (declarative) knowledge about the world cannot be supported by structures outside the MTL, even with extended exposure. Published 2004 Wiley-Liss, Inc.(dagger)
引用
收藏
页码:273 / 280
页数:8
相关论文
共 42 条
[1]
Amaral D. G., 1990, HUMAN NERVOUS SYSTEM
[2]
[Anonymous], 1983, CANADIAN PSYCHOL
[3]
Successful recollection of remote autobiographical memories by amnesic patients with medial temporal lobe lesions [J].
Bayley, PJ ;
Hopkins, RO ;
Squire, LR .
NEURON, 2003, 38 (01) :135-144
[4]
Bayley PJ, 2002, J NEUROSCI, V22, P5741
[5]
Patterns of temporal lobe atrophy in semantic dementia and Alzheimer's disease [J].
Chan, D ;
Fox, NC ;
Scahill, RI ;
Crum, WR ;
Whitwell, JL ;
Leschziner, G ;
Rossor, AM ;
Stevens, JM ;
Cipolotti, L ;
Rossor, MN .
ANNALS OF NEUROLOGY, 2001, 49 (04) :433-442
[6]
What's new with the amnesic patient HM? [J].
Corkin, S .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (02) :153-160
[7]
Corkin S, 1997, J NEUROSCI, V17, P3964
[8]
Eichenbaum H, 2004, From conditioning to conscious recollection: memory systems of the brain
[9]
Funnell E, 1995, BROKEN MEMORIES, P225
[10]
THE IMPAIRED LEARNING OF SEMANTIC KNOWLEDGE FOLLOWING BILATERAL MEDIAL TEMPORAL-LOBE RESECTION [J].
GABRIELI, JDE ;
COHEN, NJ ;
CORKIN, S .
BRAIN AND COGNITION, 1988, 7 (02) :157-177