Scabrolides A-D, four new norditerpenoids isolated from the soft coral Sinularia scabra

被引：103

作者：

Sheu, JH ^{[1
]}

Ahmed, AF

Shiue, RT

Dai, CF

Kuo, YH

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Resources, Kaohsiung 804, Taiwan

[2] Univ Mansoura, Fac Pharm, Dept Pharmacognosy, Mansoura 35516, Egypt

[3] Natl Taiwan Univ, Inst Oceanog, Taipei 106, Taiwan

[4] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 12期

关键词：

D O I：

10.1021/np020280r

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new norditerpenoids, scabrolides A-D (1-4), along with four known ones, 5-8, have been isolated from the dichloromethane extract of the Taiwanese soft coral Sinularia scabra. The structures of 1-4 were elucidated on the basis of extensive spectroscopic analyses, while the relative configurations were determined by the NOESY experiments. The epimeric metabolites 6 and 7 have been shown to exhibit strong cytotoxic activity against KB and Hepa59T/VGH cancer cell lines.

引用

页码：1904 / 1908

页数：5

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