Can cord blood cells support the cytokine storm in GvHD?

被引：17

作者：

Cohen, SBA

Wang, XN

Dickinson, A

机构：

[1] Royal Free Hosp, Anthony Nolan Res Inst, London NW3 2QG, England

[2] Newcastle Univ, Royal Victoria Infirm, Sch Clin & Lab Sci, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2000年 / 11卷 / 03期

关键词：

GvHD; cytokines; cord blood; naive T cells;

D O I：

10.1016/S1359-6101(00)00004-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cord blued has a high number of proliferating hematopoietic progenitors and is therefore used as an alternative source of hematopoietic cells for allogeneic transplantation. In addition there is a wider availability of cord blood and a lower cost of procurement compared to bone marrow. However one of the most interesting immunological benefits of a cord blood transplant that has been proposed is the low severity of Craft versus Host Disease (GVHD), This review aims to address some of the immunological reasons why this may be the case by assessing the role of cord blood cytokines in the cytokine storm of GvHD. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：185 / 197

页数：13

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