Randomized controlled trial of laparoscopic versus open colectomy for advanced colorectal cancer

被引：193

作者：

Hasegawa, H ^{[1
]}

Kabeshima, Y ^{[1
]}

Watanabe, M ^{[1
]}

Yamamoto, S ^{[1
]}

Kitajima, M ^{[1
]}

机构：

[1] Keio Univ, Sch Med, Dept Surg, Shinjuku Ku, Tokyo 1608582, Japan

来源：

SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES | 2003年 / 17卷 / 04期

关键词：

laparoscopic surgery; colorectal cancer; short-term outcome; randomized controlled trial;

D O I：

10.1007/s00464-002-8516-4

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: After confirming a favorable outcome of laparoscopic surgery for early colorectal cancer, we conducted a randomized controlled trial to compare short-term outcomes of laparoscopic and open colectomy for advanced colorectal cancer. Methods: Fifty-nine patients with T2 or T3 colorectal cancer were randomized to undergo laparoscopic (n = 29) or open (n = 30) colectomy. Median follow-up was 20 months (range, 6-34 months). Results: Operative time was longer (p < 0.0001) and blood loss (p = 0.0034) and postoperative analgesic requirement were less in the laparoscopic group than in the open group. An earlier return of bowel motility and earlier discharge from the hospital (p = 0.0164) were observed after laparoscopic surgery. Serum C-reactive protein levels on postoperative days 1 (p < 0.0001) and 4 (p = 0.0039) were lower in the laparoscopic group than in the open group. Postoperative complications did not differ between the two groups. Conclusion: Laparoscopic surgery for advanced colorectal cancer is feasible, with favorable short-term outcome.

引用

页码：636 / 640

页数：5

共 18 条

[1] Laparoscopically assisted colon resection for colon carcinoma - Perioperative results and long-term outcome [J].