共 30 条
Lipid Metabolism and Liver Disease in Hepatitis C Viral Infection
被引:18
作者:

Koike, Kazuhiko
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan

Tsutsumi, Takeya
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan

Yotsuyanagi, Hiroshi
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan

Moriya, Kyoji
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan
机构:
[1] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan
来源:
关键词:
Hepatitis C;
Hepatocellular carcinoma;
Transgenic mouse;
Core protein;
Steatosis;
Insulin resistance;
Oxidative stress;
VIRUS CORE PROTEIN;
TRANSGENIC MICE;
HEPATOCELLULAR-CARCINOMA;
OXIDATIVE STRESS;
MOUSE MODEL;
STEATOSIS;
EXPRESSION;
ACTIVATION;
HEPATOCARCINOGENESIS;
RECEPTOR;
D O I:
10.1159/000315226
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
Persistent infection with hepatitis C virus (HCV) is a major risk toward development of hepatocellular carcinoma. A number of transgenic mouse lines carrying the cDNA of HCV genome have been established and evaluated in the study of HCV pathogenesis. Among those, the studies using transgenic mouse lines that carry the HCV genome containing the core gene indicate the direct involvement of HCV in pathogenicity, including that in oncogenesis. Oxidative stress overproduction and intracellular signaling augmentation are shown to be the key events in HCV-associated hepatocarcinogenesis. Besides the data in hepatitis C patients, connecting liver fibrosis progression and the disturbance in lipid and glucose metabolisms, these mouse models also show a close relationship between HCV and metabolic alterations including hepatic steatosis and insulin resistance. Furthermore, the persistent activation of peroxisome proliferator-activated receptor-alpha has recently been found, yielding dramatic changes in the lipid metabolism and oxidative stress overproduction in cooperation with the mitochondrial dysfunction. These results would provide a clue for further understanding of the role of lipid metabolism in pathogenesis of hepatitis C including liver injury and hepatocarcinogenesis. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:24 / 30
页数:7
相关论文
共 30 条
[1]
THE HISTOLOGICAL FEATURES OF CHRONIC HEPATITIS-C AND AUTOIMMUNE CHRONIC HEPATITIS - A COMPARATIVE-ANALYSIS
[J].
BACH, N
;
THUNG, SN
;
SCHAFFNER, F
.
HEPATOLOGY,
1992, 15 (04)
:572-577

BACH, N
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED, LILLIAN & HENRY M STRATTON HANS POPPER DEPT PATHOL, BOX 1194, NEW YORK, NY 10029 USA

THUNG, SN
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED, LILLIAN & HENRY M STRATTON HANS POPPER DEPT PATHOL, BOX 1194, NEW YORK, NY 10029 USA

SCHAFFNER, F
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED, LILLIAN & HENRY M STRATTON HANS POPPER DEPT PATHOL, BOX 1194, NEW YORK, NY 10029 USA
[2]
Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets
[J].
Barba, G
;
Harper, F
;
Harada, T
;
Kohara, M
;
Goulinet, S
;
Matsuura, Y
;
Eder, G
;
Schaff, Z
;
Chapman, MJ
;
Miyamura, T
;
Brechot, C
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1997, 94 (04)
:1200-1205

Barba, G
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Harper, F
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Harada, T
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Kohara, M
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Goulinet, S
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Matsuura, Y
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Eder, G
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Schaff, Z
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Chapman, MJ
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Miyamura, T
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE

Brechot, C
论文数: 0 引用数: 0
h-index: 0
机构: NECKER UNIV,INSERM,U370,F-75015 PARIS,FRANCE
[3]
Lessons from hereditary colorectal cancer
[J].
Kinzler, KW
;
Vogelstein, B
.
CELL,
1996, 87 (02)
:159-170

Kinzler, KW
论文数: 0 引用数: 0
h-index: 0
机构:
HOWARD HUGHES MED INST,BALTIMORE,MD 21231 HOWARD HUGHES MED INST,BALTIMORE,MD 21231

Vogelstein, B
论文数: 0 引用数: 0
h-index: 0
机构:
HOWARD HUGHES MED INST,BALTIMORE,MD 21231 HOWARD HUGHES MED INST,BALTIMORE,MD 21231
[4]
EXPRESSION OF HEPATITIS-C VIRUS ENVELOPE PROTEINS IN TRANSGENIC MICE
[J].
KOIKE, K
;
MORIYA, K
;
ISHIBASHI, K
;
MATSUURA, Y
;
SUZUKI, T
;
SAITO, I
;
IINO, S
;
KUROKAWA, K
;
MIYAMURA, T
.
JOURNAL OF GENERAL VIROLOGY,
1995, 76
:3031-3038

KOIKE, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

MORIYA, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

ISHIBASHI, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

MATSUURA, Y
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

SUZUKI, T
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

SAITO, I
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

IINO, S
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

KUROKAWA, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

MIYAMURA, T
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN
[5]
Sialadenitis histologically resembling Sjogren syndrome in mice transgenic for hepatitis C virus envelope genes
[J].
Koike, K
;
Moriya, K
;
Ishibashi, K
;
Yotsuyanagi, H
;
Shintani, Y
;
Fujie, H
;
Kurokawa, K
;
Matsuura, Y
;
Miyamura, T
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1997, 94 (01)
:233-236

Koike, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Moriya, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Ishibashi, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Yotsuyanagi, H
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Shintani, Y
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Fujie, H
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Kurokawa, K
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Matsuura, Y
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN

Miyamura, T
论文数: 0 引用数: 0
h-index: 0
机构: DAIICHI PHARMACEUT CO LTD,TOKYO 134,JAPAN
[6]
PATHOLOGICAL DIAGNOSIS OF CHRONIC HEPATITIS-C - A MULTICENTER COMPARATIVE-STUDY WITH CHRONIC HEPATITIS-B
[J].
LEFKOWITCH, JH
;
SCHIFF, ER
;
DAVIS, GL
;
PERRILLO, RP
;
LINDSAY, K
;
BODENHEIMER, HC
;
BALART, LA
;
ORTEGO, TJ
;
PAYNE, J
;
DIENSTAG, JL
;
GIBAS, A
;
JACOBSON, IM
;
TAMBURRO, CH
;
CAREY, W
;
OBRIEN, C
;
SAMPLINER, R
;
VANTHIEL, DH
;
FEIT, D
;
ALBRECHT, J
;
MESCHIEVITZ, C
;
SANGHVI, B
;
VAUGHAN, RD
.
GASTROENTEROLOGY,
1993, 104 (02)
:595-603

LEFKOWITCH, JH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

SCHIFF, ER
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

DAVIS, GL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

PERRILLO, RP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

LINDSAY, K
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

BODENHEIMER, HC
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

BALART, LA
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

ORTEGO, TJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

PAYNE, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

DIENSTAG, JL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

GIBAS, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

JACOBSON, IM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

TAMBURRO, CH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

CAREY, W
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

OBRIEN, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

SAMPLINER, R
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

VANTHIEL, DH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

FEIT, D
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

ALBRECHT, J
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

MESCHIEVITZ, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

SANGHVI, B
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152

VAUGHAN, RD
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MIAMI,MIAMI,FL 33152
[7]
Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus
[J].
Lerat, H
;
Honda, M
;
Beard, MR
;
Loesch, K
;
Sun, J
;
Yang, Y
;
Okuda, M
;
Gosert, R
;
Xiao, SY
;
Weinman, SA
;
Lemon, SM
.
GASTROENTEROLOGY,
2002, 122 (02)
:352-365

Lerat, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Honda, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Beard, MR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Loesch, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Sun, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Yang, Y
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Okuda, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Gosert, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Xiao, SY
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Weinman, SA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

Lemon, SM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA
[8]
Steatosis and hepatitis C virus: mechanisms and significance for hepatic and extrahepatic disease
[J].
Lonardo, A
;
Adinolfi, LE
;
Loria, P
;
Carulli, N
;
Ruggiero, G
;
Day, CP
.
GASTROENTEROLOGY,
2004, 126 (02)
:586-597

Lonardo, A
论文数: 0 引用数: 0
h-index: 0
机构: Modena City Hosp, Div Gastroenterol & Internal Med, Modena, Italy

Adinolfi, LE
论文数: 0 引用数: 0
h-index: 0
机构: Modena City Hosp, Div Gastroenterol & Internal Med, Modena, Italy

Loria, P
论文数: 0 引用数: 0
h-index: 0
机构: Modena City Hosp, Div Gastroenterol & Internal Med, Modena, Italy

Carulli, N
论文数: 0 引用数: 0
h-index: 0
机构: Modena City Hosp, Div Gastroenterol & Internal Med, Modena, Italy

Ruggiero, G
论文数: 0 引用数: 0
h-index: 0
机构: Modena City Hosp, Div Gastroenterol & Internal Med, Modena, Italy

Day, CP
论文数: 0 引用数: 0
h-index: 0
机构: Modena City Hosp, Div Gastroenterol & Internal Med, Modena, Italy
[9]
Hepatitis C virus triggers mitochondrial permeability transition with production of reactive oxygen species, leading to DNA damage and STAT3 activation
[J].
Machida, Keigo
;
Cheng, Kevin T. -H.
;
Lai, Chao-Kuen
;
Jeng, King-Song
;
Sung, Vicky M. -H.
;
Lai, Michael M. C.
.
JOURNAL OF VIROLOGY,
2006, 80 (14)
:7199-7207

Machida, Keigo
论文数: 0 引用数: 0
h-index: 0
机构: Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

Cheng, Kevin T. -H.
论文数: 0 引用数: 0
h-index: 0
机构: Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

Lai, Chao-Kuen
论文数: 0 引用数: 0
h-index: 0
机构: Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

Jeng, King-Song
论文数: 0 引用数: 0
h-index: 0
机构: Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

Sung, Vicky M. -H.
论文数: 0 引用数: 0
h-index: 0
机构: Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA

Lai, Michael M. C.
论文数: 0 引用数: 0
h-index: 0
机构: Univ So Calif, Keck Sch Med, Dept Mol Microbiol & Immunol, Los Angeles, CA 90033 USA
[10]
The lipid droplet is an important organelle for hepatitis C virus production
[J].
Miyanari, Yusuke
;
Atsuzawa, Kimie
;
Usuda, Nobuteru
;
Watashi, Koichi
;
Hishiki, Takayuki
;
Zayas, Margarita
;
Bartenschlager, Ralf
;
Wakita, Takaji
;
Hijikata, Makoto
;
Shimotohno, Kunitada
.
NATURE CELL BIOLOGY,
2007, 9 (09)
:1089-U74

Miyanari, Yusuke
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Atsuzawa, Kimie
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Usuda, Nobuteru
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Watashi, Koichi
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Hishiki, Takayuki
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Zayas, Margarita
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Bartenschlager, Ralf
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Wakita, Takaji
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Hijikata, Makoto
论文数: 0 引用数: 0
h-index: 0
机构: Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan

Shimotohno, Kunitada
论文数: 0 引用数: 0
h-index: 0
机构:
Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan Kyoto Univ, Inst Virus Res, Dept Viral Oncol, Kyoto 6068507, Japan