Lipid Metabolism and Liver Disease in Hepatitis C Viral Infection

被引:18
作者
Koike, Kazuhiko [1 ]
Tsutsumi, Takeya [1 ]
Yotsuyanagi, Hiroshi [1 ]
Moriya, Kyoji [1 ]
机构
[1] Univ Tokyo, Grad Sch Med, Dept Gastroenterol, Bunkyo Ku, Tokyo 1138655, Japan
关键词
Hepatitis C; Hepatocellular carcinoma; Transgenic mouse; Core protein; Steatosis; Insulin resistance; Oxidative stress; VIRUS CORE PROTEIN; TRANSGENIC MICE; HEPATOCELLULAR-CARCINOMA; OXIDATIVE STRESS; MOUSE MODEL; STEATOSIS; EXPRESSION; ACTIVATION; HEPATOCARCINOGENESIS; RECEPTOR;
D O I
10.1159/000315226
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Persistent infection with hepatitis C virus (HCV) is a major risk toward development of hepatocellular carcinoma. A number of transgenic mouse lines carrying the cDNA of HCV genome have been established and evaluated in the study of HCV pathogenesis. Among those, the studies using transgenic mouse lines that carry the HCV genome containing the core gene indicate the direct involvement of HCV in pathogenicity, including that in oncogenesis. Oxidative stress overproduction and intracellular signaling augmentation are shown to be the key events in HCV-associated hepatocarcinogenesis. Besides the data in hepatitis C patients, connecting liver fibrosis progression and the disturbance in lipid and glucose metabolisms, these mouse models also show a close relationship between HCV and metabolic alterations including hepatic steatosis and insulin resistance. Furthermore, the persistent activation of peroxisome proliferator-activated receptor-alpha has recently been found, yielding dramatic changes in the lipid metabolism and oxidative stress overproduction in cooperation with the mitochondrial dysfunction. These results would provide a clue for further understanding of the role of lipid metabolism in pathogenesis of hepatitis C including liver injury and hepatocarcinogenesis. Copyright (C) 2010 S. Karger AG, Basel
引用
收藏
页码:24 / 30
页数:7
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