Cytoprotective roles for autophagy

被引：221

作者：

Moreau, Kevin ^{[1
]}

Luo, Shouqing ^{[1
]}

Rubinsztein, David C. ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge Inst Med Res, Cambridge CB2 2QQ, England

来源：

CURRENT OPINION IN CELL BIOLOGY | 2010年 / 22卷 / 02期

基金：

英国惠康基金;

关键词：

CELL-DEATH; DEGRADATION; TOXICITY; DISEASE; PROTEIN; P62; POLYGLUTAMINE; MITOCHONDRIA; INHIBITION; EXPANSIONS;

D O I：

10.1016/j.ceb.2009.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Macroautophagy (referred to as autophagy in this review) is a genetically regulated bulk degradation program conserved from yeast to humans, in which cytoplasmic substrates, such as damaged organelles and long-lived proteins, are delivered to lysosomes for degradation. In this review, we consider recent data that highlight possible mechanisms whereby autophagy mediates cytoprotective effects. These include the ability of autophagy to buffer against starvation, protect against apoptotic insults and clear mitochondria, aggregate-prone proteins and pathogens. These effects are pertinent to the roles of autophagy in normal human physiology, including the early neonatal period and ageing, as well as a variety of diseases, including cancer, neurodegenerative conditions and infectious diseases.

引用

页码：206 / 211

页数：6

共 45 条

[1] Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration [J].

Alirezaei, Mehrdad ;

Kiosses, William B. ;

Flynn, Claudia T. ;

Brady, Nathan R. ;

Fox, Howard S. .

PLOS ONE, 2008, 3 (08)

[2] Autophagy in innate immunity against intracellular bacteria [J].

Amano, Atsuo ;

Nakagawa, Ichiro ;

Yoshimori, Tamotsu .

JOURNAL OF BIOCHEMISTRY, 2006, 140 (02) :161-166

[3]

Bensaad K., 2009, EMBO J

[4] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[5] Rapamycin alleviates toxicity of different aggregate-prone proteins [J].

Berger, Z ;

Ravikumar, B ;

Menzies, FM ;

Oroz, LG ;

Underwood, BR ;

Pangalos, MN ;

Schmitt, I ;

Wullner, U ;

Evert, BO ;

O'Kane, CJ ;

Rubinsztein, DC .

HUMAN MOLECULAR GENETICS, 2006, 15 (03) :433-442

[6] Inhibition of macroautophagy triggers apoptosis [J].

Boya, P ;

González-Polo, RA ;

Casares, N ;

Perfettini, JL ;

Dessen, P ;

Larochette, N ;

Métivier, D ;

Meley, D ;

Souquere, S ;

Yoshimori, T ;

Pierron, G ;

Codogno, P ;

Kroemer, G .

MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (03) :1025-1040

[7] Autophagy, Not Apoptosis, Is Essential for Midgut Cell Death in Drosophila [J].

Denton, Donna ;

Shravage, Bhupendra ;

Simin, Rachel ;

Mills, Kathryn ;

Berry, Deborah L. ;

Baehrecke, Eric H. ;

Kumar, Sharad .

CURRENT BIOLOGY, 2009, 19 (20) :1741-1746

[8] Autophagy, Immunity, and Microbial Adaptations [J].

Deretic, Vojo ;

Levine, Beth .

CELL HOST & MICROBE, 2009, 5 (06) :527-549

[9] Shigella Phagocytic Vacuolar Membrane Remnants Participate in the Cellular Response to Pathogen Invasion and Are Regulated by Autophagy [J].

Dupont, Nicolas ;

Lacas-Gervais, Sandra ;

Bertout, Julie ;

Paz, Irit ;

Freche, Barbara ;

Van Nhieu, Guy Tran ;

van der Goot, F. Gisou ;

Sansonetti, Philippe J. ;

Lafont, Frank .

CELL HOST & MICROBE, 2009, 6 (02) :137-149

[10] The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis [J].

Duran, Angeles ;

Linares, Juan F. ;

Galvez, Anita S. ;

Wikenheiser, Kathryn ;

Flores, Juana M. ;

Diaz-Meco, Maria T. ;

Moscat, Jorge .

CANCER CELL, 2008, 13 (04) :343-354

← 1 2 3 4 5 →