Imaging non-dopaminergic function in Parkinson's disease

被引：21

作者：

Brooks, David J. ^{[1
]}

机构：

[1] Imperial Coll Sch Med, Hammersmith Hosp, Fac Med, Div Neurosci, London, England

[2] MRC Clin Sci Ctr, London, England

[3] Hammersmith Hosp, Imperial Coll London, London W12 0NN, England

来源：

MOLECULAR IMAGING AND BIOLOGY | 2007年 / 9卷 / 04期

基金：

英国医学研究理事会;

关键词：

positron emission tomography; Parkinson's disease; acetylcholine; serotonin; noradrenaline; microglia;

D O I：

10.1007/s11307-007-0084-5

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

In Parkinson's disease (PD), there is degeneration of the cholinergic, noradrenergic, and serotonergic systems in addition to dopaminergic projections. Function of these non-dopaminergic systems can be imaged with positron emission tomography (PET) and single photon emission computed tomography (SPECT) and correlated with motor and nonmotor symptomatology. In addition, neuronal loss in PD is associated with microglial activation. The role of microglia in driving the disease process remains uncertain. This review presents and discusses current findings in these areas.

引用

页码：217 / 222

页数：6

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