New Concepts of Microbial Translocation in the Neonatal Intestine: Mechanisms and Prevention

被引：103

作者：

Sherman, Michael P. ^{[1
]}

机构：

[1] Univ Missouri, Childrens Hosp, Dept Child Hlth, Columbia, MO 65201 USA

来源：

CLINICS IN PERINATOLOGY | 2010年 / 37卷 / 03期

关键词：

Intestinal microbiota; Enterocytes; goblet cells; and Paneth cells; Lactoferrin; probiotics; and prebiotics; LATE-ONSET SEPSIS; NECROTIZING ENTEROCOLITIS; PANETH CELLS; PRETERM INFANTS; HUMAN-MILK; BACTERIAL TRANSLOCATION; EPITHELIAL-CELLS; DEFENSIN EXPRESSION; BOVINE LACTOFERRIN; PREMATURE-INFANTS;

D O I：

10.1016/j.clp.2010.05.006

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Bacterial translocation from the gastrointestinal tract is an important pathway initiating late-onset sepsis and necrotizing enterocolitis in very low-birth-weight infants. The emerging intestinal microbiota, nascent intestinal epithelia, naive immunity, and suboptimal nutrition (lack of breast milk) have roles in facilitating bacterial translocation. Feeding lactoferrin, probiotics, or prebiotics has presented exciting possibilities to prevent bacterial translocation in preterm infants, and clinical trials will identify the most safe and efficacious prevention and treatment strategies.

引用

页码：565 / +

页数：16

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