Complete N-1 regiocontrol in the formation of N-arylimidazoles.: Synthesis of the active site His-Tyr side chain coupled dipeptide of cytochrome c oxidase

被引：80

作者：

Elliott, GI ^{[1
]}

Konopelski, JP ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 20期

关键词：

D O I：

10.1021/ol006271w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Under catalysis by copper(II) acetate, complete regiocontrol (N-1 versus N-3) was obtained in the arylation of substituted imidazoles with aryllead(IV) reagents. The mildness of the reaction conditions (rt, no added base) allows for the first synthesis of the histidine-tyrosine side chain coupled dipeptide found in the active site of cytochrome c oxidase.

引用

页码：3055 / 3057

页数：3

共 37 条

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