Elevation of the γ-aminobutyric acid transaminase expression in the gerbil CA1 area after ischemia-reperfusion damage

被引:18
作者
Kang, TC
Park, SK
Bahn, JH
Chang, JS
Koh, WS
Jo, SM
Cho, SW
Choi, SY
Won, MH [1 ]
机构
[1] Hallym Univ, Coll Med, Dept Anat, Chunchon 200702, Kangwon Do, South Korea
[2] Hallym Univ, Coll Life Sci, Dept Genet Engn, Chunchon 200702, Kangwon Do, South Korea
[3] Hallym Univ, Coll Med, Dept Neurol, Chunchon 200702, Kangwon Do, South Korea
[4] Univ Ulsan, Coll Med, Dept Biochem, Seoul 138736, South Korea
关键词
gamma-aminobutyric acid-transaminase; ischemia; hippocampus; immunohistochemistry; gerbil;
D O I
10.1016/S0304-3940(00)01541-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
gamma -Aminobutyric acid-transaminase (GABA-T) plays an important role in the metabolism of GABA, particularly in the neurons or glial cells. The present study was undertaken to determine the alteration of GABA-T expression in the gerbil hippocampus after ischemia-reperfusion. In the sham, GABA-T+ neurons were scattered in the hippocampus proper and dentate gyrus. The intensity of the GABA-T immunoreactivity had nearly disappeared in the interneurons at 12 h after ischemia. In contrast, 24 h post-ischemia the dramatic augmentation of GABA-T immunoreactivity in the pyramidal cells was observed in the CA1 area but not in the CA2 or CA3 areas. Forty-eight hours after ischemia-reperfusion, its immunoreactivity was preserved in the CA1 neurons. These results suggest that the over-expression of GABA-T in the CA1 area may be related to delayed neuronal death after ischemia-reperfussoo insult. (C) 2000 Published by Elsevier Science Ireland Ltd.
引用
收藏
页码:33 / 36
页数:4
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