Blazeispirol X and Y, two novel carbon skeletal sterols from the cultured mycelia of the fungus Agaricus blazei

被引：14

作者：

Hirotani, M ^{[1
]}

Hirotani, S ^{[1
]}

Yoshikawa, T ^{[1
]}

机构：

[1] Kitasato Univ, Sch Pharmaceut Sci, Minato Ku, Tokyo 1088641, Japan

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 26期

关键词：

fungi; natural products; NMR; steroid;

D O I：

10.1016/S0040-4039(00)00783-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学]; 081704 [应用化学];

摘要：

Two novel blazeispirol derivatives, blazeispirol X and Y, have been isolated from the cultured mycelia of Agaricus blazei (Agaricaceae). The structures were elucidated to be (20S,22S,23R,24S)-1 (10-->6) abeo-14 beta,22:22,25-diepoxyergosta-5,7,9,11-tetraene-3 alpha,23-diol and (20S,22S,23R,24S)-14 beta,22:22,25-diepoxy-9,23-dihydroxyergosta-4,7,11-triene-3,6-dione by comparison of extensive 1D and 2D NMR spectral data with that of blazeispirol A. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5107 / 5110

页数：4

共 9 条

[1]

PYRIDINE-INDUCED SOLVENT SHIFTS IN NUCLEAR MAGNETIC RESONANCE SPECTRA OF HYDROXYLIC COMPOUNDS [J].

DEMARCO, PV ;

FARKAS, E ;

DODDRELL, D ;

MYLARI, BL ;

WENKERT, E .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (20) :5480-&

[2]

UNSATURATED STEROIDS .10. THE MECHANISM OF THE ANTHRASTEROID REARRANGEMENT - THE CONFORMATION OF ANTHRASTEROIDS [J].

EMKE, A ;

MIDGLEY, JM ;

WHALLEY, WB .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1980, (08) :1779-1781

[3]

Blazeispirol A, an unprecedented skeleton from the cultured mycelia of the fungus Agaricus blazei [J].

Hirotani, M ;

Hirotani, S ;

Takayanagi, H ;

Yoshikawa, T .

TETRAHEDRON LETTERS, 1999, 40 (02) :329-332

[4]

STUDIES ON THE METABOLITES OF HIGHER FUNGI .7. GANODERIC ACID-DERIVATIVES AND ERGOSTA-4,7,22-TRIENE-3,6-DIONE FROM GANODERMA-LUCIDUM [J].

HIROTANI, M ;

ASAKA, I ;

INO, C ;

FURUYA, T ;

SHIRO, M .

PHYTOCHEMISTRY, 1987, 26 (10) :2797-2803

[5]

C-27-C-29 MONAROMATIC ANTHRASTEROID HYDROCARBONS IN CRETACEOUS BLACK SHALES [J].

HUSSLER, G ;

ALBRECHT, P .

NATURE, 1983, 304 (5923) :262-263

[6]

2 STEROIDS FROM CALVATIA-CYATHIFORMIS [J].

KAWAHARA, N ;

SEKITA, S ;

SATAKE, M .

PHYTOCHEMISTRY, 1995, 38 (04) :947-950

[7]

CITREOANTHRASTEROID, A NEW METABOLITE OF A HYBRID STRAIN KO-0011 DERIVED FROM PENICILLIUM CITREO-VIRIDE-B IFO-6200 AND IFO-4692 [J].

KOSEMURA, S ;

UOTSU, S ;

YAMAMURA, S .

TETRAHEDRON LETTERS, 1995, 36 (41) :7481-7482

[8]

A RING-B AROMATIC STEROL FROM STROMATA OF EPICHLOE-TYPHINA [J].

KOSHINO, H ;

YOSHIHARA, T ;

SAKAMURA, S ;

SHIMANUKI, T ;

SATO, T ;

TAJIMI, A .

PHYTOCHEMISTRY, 1989, 28 (03) :771-772

[9]

TURNER WB, 1983, FUNGAL METABOLITES, V2, P225

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