Developments in technology and applications of microsystems

被引:101
作者
Kopp, MU [1 ]
Crabtree, HJ [1 ]
Manz, A [1 ]
机构
[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, Zeneca SmithKline Beecham Ctr Analyt Sci, London SW7 2AY, England
关键词
D O I
10.1016/S1367-5931(97)80081-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the past year, microchips as applied to miniaturised total analysis systems, or mu TAS, have benefited from technological improvements in their fabrication and been applied to analysis in many different biological areas. From a technological perspective, salient work includes fast, cheap and easy micromachining in polymers and integrated optical detection. From the bioapplications perspective, advances in DNA and protein separations, cell manipulations, immunoassays and polymerase chain reaction using on-chip electrophoretic separation stand out.
引用
收藏
页码:410 / 419
页数:10
相关论文
共 45 条
[1]  
ANDERSSON PE, 1997, 1997 INT C SOL STAT, V2, P1311
[2]   SEPARATION OF HUMAN BREAST-CANCER CELLS FROM BLOOD BY DIFFERENTIAL DIELECTRIC AFFINITY [J].
BECKER, FF ;
WANG, XB ;
HUANG, Y ;
PETHIG, R ;
VYKOUKAL, J ;
GASCOYNE, PRC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (03) :860-864
[3]   Microfabricated structures for integrated DNA analysis [J].
Burns, MA ;
Mastrangelo, CH ;
Sammarco, TS ;
Man, FP ;
Webster, JR ;
Johnson, BN ;
Foerster, B ;
Jones, D ;
Fields, Y ;
Kaiser, AR ;
Burke, DT .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) :5556-5561
[4]   Chip PCR .2. Investigation of different PCR amplification systems in microfabricated silicon-glass chips [J].
Cheng, J ;
Shoffner, MA ;
Hvichia, GE ;
Kricka, LJ ;
Wilding, P .
NUCLEIC ACIDS RESEARCH, 1996, 24 (02) :380-385
[5]   Analysis of ligase chain reaction products amplified in a silicon-glass chip using capillary electrophoresis [J].
Cheng, J ;
Shoffner, MA ;
Mitchelson, KR ;
Kricka, LJ ;
Wilding, P .
JOURNAL OF CHROMATOGRAPHY A, 1996, 732 (01) :151-158
[6]   Microchip-based capillary electrophoresis for immunoassays: Analysis of monoclonal antibodies and theophylline [J].
Chiem, N ;
Harrison, DJ .
ANALYTICAL CHEMISTRY, 1997, 69 (03) :373-378
[7]  
CHIEM N, 1997, 1997 INT C SOL STAT, V1, P187
[8]   Porous silicon as the carrier matrix in microstructured enzyme reactors yielding high enzyme activities [J].
Drott, J ;
Lindstrom, K ;
Rosengren, L ;
Laurell, T .
JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 1997, 7 (01) :14-23
[9]   MANIPULATION OF SAMPLE FRACTIONS ON A CAPILLARY ELECTROPHORESIS CHIP [J].
EFFENHAUSER, CS ;
MANZ, A ;
WIDMER, HM .
ANALYTICAL CHEMISTRY, 1995, 67 (13) :2284-2287
[10]   HIGH-SPEED SEPARATION OF ANTISENSE OLIGONUCLEOTIDES ON A MICROMACHINED CAPILLARY ELECTROPHORESIS DEVICE [J].
EFFENHAUSER, CS ;
PAULUS, A ;
MANZ, A ;
WIDMER, HM .
ANALYTICAL CHEMISTRY, 1994, 66 (18) :2949-2953